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Literature summary for 3.13.2.1 extracted from

  • Bozzi, A.; Parisi, M.; Martini, F.
    Adenosine analogues as inhibitors or inactivators of S-adenosylhomocysteine hydrolase from bovine pancreas (1993), J. Enzyme Inhib., 7, 159-167.
No PubMed abstract available
Search for more literature for 3.13.2.1

Application

Application Comment Organism
medicine antiviral drug design Bos taurus
medicine antineoplastic drug design Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
2'-deoxyadenosine
-
 Bos taurus
2-chloroadenosine
-
 Bos taurus
3-deaza-(+/-)-aristeromycin
-
 Bos taurus
3-deazaadenosine
-
 Bos taurus
Inosine
-
 Bos taurus
nebularine
-
 Bos taurus
tubercidin
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.008
-
 adenosine
-
 Bos taurus
0.042
-
 S-adenosyl-L-homocysteine
-
 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-homocysteine + H2O Bos taurus
-
 adenosine + L-homocysteine
-
 r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity Bos taurus

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Bos taurus
a

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-homocysteine + adenosine
-
 Bos taurus S-adenosyl-DL-homocysteine
-
 r
S-adenosyl-L-homocysteine + H2O
-
 Bos taurus adenosine + L-homocysteine
-
 r