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Literature summary for 3.13.2.1 extracted from
- Inhibition studies of S-adenosylhomocysteine hydrolase purified from Acinetobacter calcoaceticus ULA-501 (1996), Biochimie, 78, 267-272.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2'-deoxyadenosine | - |
Acinetobacter calcoaceticus |  |
| 2'-deoxyadenosine | - |
Bos taurus | |
| 2-chloroadenosine | - |
Acinetobacter calcoaceticus | |
| 2-chloroadenosine | - |
Bos taurus | |
| 3-deaza-(+/-)-aristeromycin | - |
Acinetobacter calcoaceticus | |
| 3-deaza-(+/-)-aristeromycin | - |
Bos taurus | |
| 3-deazaadenosine | - |
Acinetobacter calcoaceticus | |
| 3-deazaadenosine | - |
Bos taurus | |
| cis-diaminedichloride platinum | - |
Acinetobacter calcoaceticus | |
| cis-diaminedichloride platinum | - |
Bos taurus | |
| KCl | with ATP-Mg acetate | Acinetobacter calcoaceticus | |
| KCl | with ATP-Mg acetate | Bos taurus | |
| sinefungin | - |
Acinetobacter calcoaceticus | |
| trans-diaminedichloride platinum | - |
Acinetobacter calcoaceticus | |
| trans-diaminedichloride platinum | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0016 | - |
adenosine | - |
Acinetobacter calcoaceticus | |
| 0.008 | - |
adenosine | - |
Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-homocysteine + H2O | Bos taurus | - |
adenosine + L-homocysteine | - |
r | |
| S-adenosyl-L-homocysteine + H2O | Acinetobacter calcoaceticus | - |
adenosine + L-homocysteine | - |
r | |
| S-adenosyl-L-homocysteine + H2O | Acinetobacter calcoaceticus ULA-501 | - |
adenosine + L-homocysteine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acinetobacter calcoaceticus | - |
ULA-501 | - |
| Acinetobacter calcoaceticus ULA-501 | - |
ULA-501 | - |
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| to homogeneity | Acinetobacter calcoaceticus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine | reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine | Bos taurus | |
| S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine | reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine | Acinetobacter calcoaceticus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| pancreas | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DL-homocysteine + adenosine | - |
Bos taurus | S-adenosyl-DL-homocysteine | - |
r | |
| DL-homocysteine + adenosine | - |
Acinetobacter calcoaceticus | S-adenosyl-DL-homocysteine | - |
r | |
| DL-homocysteine + adenosine | - |
Acinetobacter calcoaceticus ULA-501 | S-adenosyl-DL-homocysteine | - |
r | |
| S-adenosyl-L-homocysteine + H2O | - |
Bos taurus | adenosine + L-homocysteine | - |
r | |
| S-adenosyl-L-homocysteine + H2O | - |
Acinetobacter calcoaceticus | adenosine + L-homocysteine | - |
r | |
| S-adenosyl-L-homocysteine + H2O | - |
Acinetobacter calcoaceticus ULA-501 | adenosine + L-homocysteine | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | - |
Acinetobacter calcoaceticus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Bos taurus | |
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