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Literature summary for 3.13.2.1 extracted from
- Trichomonas vaginalis: Expression and characterization of recombinant S-adenosylhomocysteinase (1998), Exp. Parasitol., 90, 175-180.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | antiviral drug design | Trichomonas vaginalis |
| medicine | anti-parasitic drug design | Trichomonas vaginalis |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| into Escherichia coli | Trichomonas vaginalis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| arabinosyladenine | - |
Trichomonas vaginalis |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.005 | 0.01 | adenosine | native enzyme | Trichomonas vaginalis | |
| 0.02 | 0.025 | adenosine | recombinant enzyme | Trichomonas vaginalis | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | - |
gel filtration and SDS-PAGE | Trichomonas vaginalis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-homocysteine + H2O | Trichomonas vaginalis | - |
adenosine + L-homocysteine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trichomonas vaginalis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Trichomonas vaginalis |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.32 | - |
recombinant enzyme | Trichomonas vaginalis |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, in 50% glycerol, stable for at least 1 month | Trichomonas vaginalis |
| -70°C, in 50% glycerol, stable for at least 1 month | Trichomonas vaginalis |
| 4°C, stable for at least 1 month | Trichomonas vaginalis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-homocysteine + H2O | - |
Trichomonas vaginalis | adenosine + L-homocysteine | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | monomer is enzymatically active, 1 * 55000, SDS-PAGE | Trichomonas vaginalis |
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Release 2023.1 (January 2023)
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