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Literature summary for 3.13.2.1 extracted from

  • Jarvi, E.T.; McCarthy, J.R.; Mehdi, S.; Matthews, D.P.; Edwards, M.L.; Prakash, N.J.; Bowlin, T.L.; Sunkara, P.S.; Bey, P.
    4',5'-Unsaturated 5'-halogenated nucleosides. Mechanism-based and competitive inhibitors of S-adenosyl-L-homocysteine hydrolase (1991), J. Med. Chem., 34, 647-656.
    View publication on PubMed
Search for more literature for 3.13.2.1

Activating Compound

Activating Compound Comment Organism Structure
adenosine prevents inhibition by (Z)-9-(5-deoxy-5-fluoro-beta-D-erythro-pent-4-enofuranosyl)adenine Mus musculus

Application

Application Comment Organism
medicine antiviral drug design Mus musculus
medicine antiviral drug design Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
(E)-4',5'-didehydro-2',5'-dideoxy-5'-fluoroadenosine
-
 Rattus norvegicus
(E)-4',5'-didehydro-5'-deoxy-5'-chloro-5'-fluoroadenosine competitive Rattus norvegicus
(E)-9-(5-deoxy-5-fluoro-beta-D-erythro-pent-4-enofuranosyl)adenine
-
 Mus musculus
(E)-9-(5-deoxy-5-fluoro-beta-D-erythro-pent-4-enofuranosyl)adenine
-
 Rattus norvegicus
(E)-9-(5-deoxy-5-fluoro-beta-D-threo-pent-4-enofuranosyl)-9H-purin-6-amine competitive Rattus norvegicus
(Z)-4',5'-didehydro-2',5'-dideoxy-5'-fluoroadenosine competitive Rattus norvegicus
(Z)-4',5'-didehydro-5'-chloro-5'-deoxyadenosine competitive Rattus norvegicus
(Z)-4',5'-didehydro-5'-deoxy-5'-chloro-5'-fluoroadenosine competitive Rattus norvegicus
(Z)-9-(5-deoxy-5-fluoro-beta-D-erythro-pent-4-enofuranosyl)adenine
-
 Mus musculus
(Z)-9-(5-deoxy-5-fluoro-beta-D-erythro-pent-4-enofuranosyl)adenine
-
 Rattus norvegicus
(Z)-9-(5-deoxy-5-fluoro-beta-D-threo-pent-4-enofuranosyl)-9H-purin-6-amine competitive Rattus norvegicus
5'-deoxy-5',5'-difluoradenosine
-
 Mus musculus
5'-deoxy-5',5'-difluoradenosine
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-homocysteine + H2O Mus musculus
-
 adenosine + L-homocysteine
-
 r
S-adenosyl-L-homocysteine + H2O Rattus norvegicus
-
 adenosine + L-homocysteine
-
 r

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus
partial Mus musculus

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Mus musculus
a
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-
liver
-
 Rattus norvegicus
-

Storage Stability

Storage Stability Organism
-70°C Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-homocysteine + adenosine
-
 Mus musculus S-adenosyl-DL-homocysteine
-
 r
DL-homocysteine + adenosine
-
 Rattus norvegicus S-adenosyl-DL-homocysteine
-
 r
S-adenosyl-L-homocysteine + H2O
-
 Mus musculus adenosine + L-homocysteine
-
 r
S-adenosyl-L-homocysteine + H2O
-
 Rattus norvegicus adenosine + L-homocysteine
-
 r