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Literature summary for 3.13.2.1 extracted from

  • Wnuk, S.F.; Yuan, C.S.; Borchardt, R.T.; Balzarini, J.; De Clercq, E.; Robins, M.J.
    Anticancer and antiviral effects and inactivation of S-adenosyl-L-homocysteine hydrolase with 5'-carboxyaldehydes and oximes synthesized from adenosine and sugar-modified analogues (1997), J. Med. Chem., 40, 1608-1628.
    View publication on PubMed
Search for more literature for 3.13.2.1

Application

Application Comment Organism
medicine antiviral drug design Homo sapiens
medicine chemotherapeutic drug design Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
9-(2-deoxy-beta-D-erythro-pentodialdo-1,4-furanosyl)adenine
-
 Homo sapiens
9-(2-deoxy-beta-D-erythro-pentodialdo-1,4-furanosyl)adenine oxime (E/Z) Homo sapiens
9-(3-deoxy-beta-D-erythro-pentodialdo-1,4-furanosyl)adenine
-
 Homo sapiens
9-(3-deoxy-beta-D-erythro-pentodialdo-1,4-furanosyl)adenine oxime (E/Z) Homo sapiens
9-(alpha-L-lyxo-pentodialdo-1,4-furanosyl)adenine
-
 Homo sapiens
9-(alpha-L-lyxo-pentodialdo-1,4-furanosyl)adenine oxime (E/Z) Homo sapiens
9-(beta-D-arabino-pentodialdo-1,4-furanosyl)adenine
-
 Homo sapiens
9-(beta-D-arabino-pentodialdo-1,4-furanosyl)adenine oxime (E/Z) Homo sapiens
9-(beta-D-ribo-pentodialdo-1,4-furanosyl)adenine
-
 Homo sapiens
9-(beta-D-ribo-pentodialdo-1,4-furanosyl)adenine (adenosine-5'-carboxaldehyde)
-
 Homo sapiens
9-(beta-D-ribo-pentodialdo-1,4-furanosyl)adenine O-benzyloxime (E/Z) Homo sapiens
9-(beta-D-ribo-pentodialdo-1,4-furanosyl)adenine O-ethyloxime (E/Z) Homo sapiens
9-(beta-D-ribo-pentodialdo-1,4-furanosyl)adenine O-methyloxime (E/Z) Homo sapiens
9-(beta-D-ribo-pentodialdo-1,4-furanosyl)adenine oxime (E/Z) Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-homocysteine + H2O Homo sapiens
-
 adenosine + L-homocysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-homocysteine + H2O
-
 Homo sapiens adenosine + L-homocysteine
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Homo sapiens