Literature summary for 3.13.2.1 extracted from

Walker, R.D.; Duerre, J.A.
S-Adenosylhomocysteine metabolism in various species (1975), Can. J. Biochem., 53, 312-319.

Inhibitors

Inhibitors	Comment	Organism
adenine	-	Rattus norvegicus
adenine	-	Saccharomyces cerevisiae
adenosine	-	Rattus norvegicus
L-homocysteine	-	Rattus norvegicus
L-homocysteine	-	Saccharomyces cerevisiae
S-adenosyl-L-homocysteine	-	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.5	-	adenosine	-	Rattus norvegicus
4.5	-	L-homocysteine	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
S-adenosyl-L-homocysteine + H2O	Gallus gallus	-	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	Phaseolus vulgaris	-	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	Cyberlindnera jadinii	-	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	Rattus norvegicus	-	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	Saccharomyces cerevisiae	-	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	Oryctolagus cuniculus	-	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	Spinacia oleracea	-	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	Zea mays	-	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	Canis lupus familiaris	-	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	Candida albicans	-	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	Hordeum vulgare subsp. vulgare	-	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	Rattus norvegicus Sprague-Dawley	-	adenosine + L-homocysteine	-	r

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	-	-
Canis lupus familiaris	-	-	-
Cyberlindnera jadinii	-	-	-
Gallus gallus	-	white leghorn	-
Hordeum vulgare subsp. vulgare	-	barley	-
Oryctolagus cuniculus	-	-	-
Phaseolus vulgaris	-	green bean	-
Rattus norvegicus	-	Sprague-Dawley	-
Rattus norvegicus Sprague-Dawley	-	Sprague-Dawley	-
Saccharomyces cerevisiae	-	-	-
Spinacia oleracea	-	spinach	-
Zea mays	-	field corn	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus

Reaction

Reaction	Comment	Organism	Reaction ID
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine	reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine	Gallus gallus	a
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine	reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine	Phaseolus vulgaris	a
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine	reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine	Cyberlindnera jadinii	a
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine	reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine	Rattus norvegicus	a
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine	reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine	Saccharomyces cerevisiae	a
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine	reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine	Oryctolagus cuniculus	a
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine	reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine	Spinacia oleracea	a
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine	reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine	Zea mays	a
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine	reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine	Canis lupus familiaris	a
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine	reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine	Candida albicans	a
S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine	reaction equilibrium is in vitro strongly in direction of synthesis of S-adenosyl-L-homocysteine	Hordeum vulgare subsp. vulgare	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	very low level	Gallus gallus	-
brain	very low level	Rattus norvegicus	-
brain	very low level	Oryctolagus cuniculus	-
brain	very low level	Canis lupus familiaris	-
heart	very low level	Gallus gallus	-
heart	very low level	Rattus norvegicus	-
heart	very low level	Oryctolagus cuniculus	-
heart	very low level	Canis lupus familiaris	-
kidney	-	Gallus gallus	-
kidney	-	Rattus norvegicus	-
kidney	-	Oryctolagus cuniculus	-
kidney	-	Canis lupus familiaris	-
leaf	-	Phaseolus vulgaris	-
leaf	-	Spinacia oleracea	-
liver	-	Gallus gallus	-
liver	-	Rattus norvegicus	-
liver	-	Oryctolagus cuniculus	-
liver	-	Canis lupus familiaris	-
pancreas	-	Gallus gallus	-
pancreas	-	Rattus norvegicus	-
pancreas	-	Oryctolagus cuniculus	-
pancreas	-	Canis lupus familiaris	-
seedling	etiolated	Phaseolus vulgaris	-
seedling	etiolated	Zea mays	-
seedling	etiolated	Hordeum vulgare subsp. vulgare	-
spleen	low level	Gallus gallus	-
spleen	low level	Rattus norvegicus	-
spleen	low level	Oryctolagus cuniculus	-
spleen	low level	Canis lupus familiaris	-
testis	low level	Gallus gallus	-
testis	low level	Rattus norvegicus	-
testis	low level	Oryctolagus cuniculus	-
testis	low level	Canis lupus familiaris	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.00003	0.0003	differs, depending on which organ is examined, hydrolysis of S-adenosyl-L-homocysteine, crude extract	Canis lupus familiaris
0.00005	0.00036	differs, depending on which organ is examined, hydrolysis of S-adenosyl-L-homocysteine, crude extract	Gallus gallus
0.00008	0.00091	differs, depending on which organ is examined, hydrolysis of S-adenosyl-L-homocysteine, crude extract	Rattus norvegicus
0.00008	0.00092	differs, depending on which organ is examined, hydrolysis of S-adenosyl-L-homocysteine, crude extract	Oryctolagus cuniculus
0.0027	-	crude extract	Spinacia oleracea
0.0031	0.09	differs, depending on which organ is examined, synthesis of S-adenosyl-L-homocysteine, crude extract	Rattus norvegicus
0.0033	0.0259	differs, depending on which organ is examined, synthesis of S-adenosyl-L-homocysteine, crude extract	Gallus gallus
0.0055	0.0588	differs, depending on which organ is examined, synthesis of S-adenosyl-L-homocysteine, crude extract	Oryctolagus cuniculus
0.01	-	crude extract	Candida albicans
0.012	-	crude extract	Cyberlindnera jadinii
0.0127	-	crude extract	Phaseolus vulgaris
0.015	-	crude extract	Saccharomyces cerevisiae
0.0215	-	crude extract	Hordeum vulgare subsp. vulgare
0.0356	-	up to this value, differs, depending on which organ is examined, synthesis of S-adenosyl-L-homocysteine, crude extract	Canis lupus familiaris
0.0615	-	crude extract	Phaseolus vulgaris
0.0707	-	crude extract	Zea mays

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
S-adenosyl-L-homocysteine + H2O	-	Gallus gallus	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	-	Phaseolus vulgaris	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	-	Cyberlindnera jadinii	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	-	Rattus norvegicus	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	-	Saccharomyces cerevisiae	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	-	Oryctolagus cuniculus	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	-	Spinacia oleracea	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	-	Zea mays	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	-	Canis lupus familiaris	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	-	Candida albicans	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	-	Hordeum vulgare subsp. vulgare	adenosine + L-homocysteine	-	r
S-adenosyl-L-homocysteine + H2O	-	Rattus norvegicus Sprague-Dawley	adenosine + L-homocysteine	-	r