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Literature summary for 3.13.2.1 extracted from

  • Fujioka, M.; Takata, Y.
    S-Adenosylhomocysteine hydrolase from rat liver. Purification and some properties (1981), J. Biol. Chem., 256, 1631-1635.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
bisulfite reversible Rattus norvegicus
DL-homocysteine competitive Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00105
-
adenosine
-
Rattus norvegicus
0.0152
-
S-adenosyl-L-homocysteine
-
Rattus norvegicus
0.1548
-
DL-homocysteine
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
47000
-
4 * 47000, SDS-PAGE, probably homomeric Rattus norvegicus
188000
-
gel filtration Rattus norvegicus
190000
-
sedimentation equilibrium Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-homocysteine + H2O Rattus norvegicus
-
adenosine + L-homocysteine
-
r

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Wistar rats
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.77
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-homocysteine + 3-deazaadenosine
-
Rattus norvegicus ?
-
r
DL-homocysteine + adenosine
-
Rattus norvegicus S-adenosyl-DL-homocysteine
-
r
S-adenosyl-L-homocysteine + H2O
-
Rattus norvegicus adenosine + L-homocysteine
-
r

Subunits

Subunits Comment Organism
tetramer 4 * 47000, SDS-PAGE, probably homomeric Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.4 7.2 hydrolysis of S-adenosyl-L-homocysteine Rattus norvegicus
7.8
-
synthesis of S-adenosyl-L-homocysteine Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus