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Literature summary for 3.1.8.2 extracted from

  • Petrikovics, I.; Cheng, T.C.; Papahadjopoulos, D.; Hong, K.; Yin, R.; DeFrank, J.J.; Jaing, J.; Song, Z.H.; McGuinn, W.D.; Sylvester, D.; Pei, L.; Madec, J.; Tamulinas, C.; Jaszberenyi, J.C.; Barcza, T.; Way, J.L.
    Long circulating liposomes encapsulating organophosphorus acid anhydrolase in diisopropylfluorophosphate antagonism (2000), Toxicol. Sci., 57, 16-21.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information an approach using recombinant enzyme encapsulated within sterically stabilized liposomes to enhance diisopropyl fluorophosphates degradation Alteromonas sp.

Application

Application Comment Organism
degradation enzyme catalyse the hydrolysis of toxic organophosphorus cholinesterase-inhibiting compounds, including pesticides and chemical nerve agents Alteromonas sp.
degradation approach to the use of enzyme encapsulated within liposomes, to protect against and treat chemical poisoning Alteromonas sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.57
-
sarin
-
Alteromonas sp.
2.48
-
soman
-
Alteromonas sp.
2.99
-
diisopropyl fluorophosphate
-
Alteromonas sp.
14.2
-
paraoxon
-
Alteromonas sp.

Organism

Organism UniProt Comment Textmining
Alteromonas sp.
-
liposomes encapsulating enzyme
-

Storage Stability

Storage Stability Organism
37Ā°C, liposomes encapsulating enzyme incubated in blood, stable over 2 days Alteromonas sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diisopropyl fluorophosphate + H2O
-
Alteromonas sp. diisopropyl phosphate + fluoride
-
?
paraoxon + H2O
-
Alteromonas sp. diethylphosphate + 4-nitrophenol
-
?
sarin + H2O
-
Alteromonas sp. ?
-
?
soman + H2O
-
Alteromonas sp. ?
-
?