Literature summary for 3.1.8.2 extracted from

Petrikovics, I.; Cheng, T.C.; Papahadjopoulos, D.; Hong, K.; Yin, R.; DeFrank, J.J.; Jaing, J.; Song, Z.H.; McGuinn, W.D.; Sylvester, D.; Pei, L.; Madec, J.; Tamulinas, C.; Jaszberenyi, J.C.; Barcza, T.; Way, J.L.
Long circulating liposomes encapsulating organophosphorus acid anhydrolase in diisopropylfluorophosphate antagonism (2000), Toxicol. Sci., 57, 16-21.

Search for more literature for 3.1.8.2

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	an approach using recombinant enzyme encapsulated within sterically stabilized liposomes to enhance diisopropyl fluorophosphates degradation	Alteromonas sp.

Application

Application	Comment	Organism
degradation	enzyme catalyse the hydrolysis of toxic organophosphorus cholinesterase-inhibiting compounds, including pesticides and chemical nerve agents	Alteromonas sp.
degradation	approach to the use of enzyme encapsulated within liposomes, to protect against and treat chemical poisoning	Alteromonas sp.

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.57	-	sarin	-	Alteromonas sp.
2.48	-	soman	-	Alteromonas sp.
2.99	-	diisopropyl fluorophosphate	-	Alteromonas sp.
14.2	-	paraoxon	-	Alteromonas sp.

Organism

Organism	UniProt	Comment	Textmining
Alteromonas sp.	-	liposomes encapsulating enzyme	-

Storage Stability

Storage Stability	Organism
37°C, liposomes encapsulating enzyme incubated in blood, stable over 2 days	Alteromonas sp.

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
diisopropyl fluorophosphate + H2O	-	Alteromonas sp.	diisopropyl phosphate + fluoride	-	?
paraoxon + H2O	-	Alteromonas sp.	diethylphosphate + 4-nitrophenol	-	?
sarin + H2O	-	Alteromonas sp.	?	-	?
soman + H2O	-	Alteromonas sp.	?	-	?

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Release 2023.1 (January 2023)