Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bis(cyclopropylmethyl) phosphoramidate | paraoxon analogue with predominant active site binding mode | synthetic construct | |
bis[4-(methylsulfanyl)phenyl] phosphorazidate | paraoxon analogue with predominant active site binding mode | synthetic construct | |
dibenzyl phosphoramidate | paraoxon analogue with predominant active site binding mode | synthetic construct |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
synthetic construct | - |
recombinant PON1 variant G2E6 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
paraoxon + H2O | - |
synthetic construct | 4-nitrophenol + diethyl phosphate | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.03 | - |
pH 7.4, temperature not specified in the publication | synthetic construct | dibenzyl phosphoramidate | |
0.1 | 0.5 | pH 7.4, temperature not specified in the publication | synthetic construct | bis(cyclopropylmethyl) phosphoramidate | |
0.3 | - |
pH 7.4, temperature not specified in the publication | synthetic construct | bis[4-(methylsulfanyl)phenyl] phosphorazidate |