Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diisopropylfluorophosphate | IC50: 0.8 for 65 kDa BPP hydrolase | Salvia officinalis | |
diphosphate | IC50: 0.6 for 65 kDa BPP hydrolase, 2.5 for 20 kDa BPP hydrolase | Salvia officinalis | |
F- | IC50: 0.7 mM for 65 kDa BPP hydrolase, 15.5 mM for 20 kDa BPP hydrolase | Salvia officinalis | |
Mn2+ | IC50: 0.1 mM for 65 kDa BPP hydrolase, 15.0 mM for 20 kDa BPP hydrolase | Salvia officinalis | |
phosphate | IC50: 10.5 mM for 65 kDa BPP hydrolase, 4.3 for 20 kDa BPP hydrolase | Salvia officinalis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.023 | - |
D-bornyl-diphosphate | 65 kDa BPP hydrolase | Salvia officinalis | |
0.12 | - |
D-bornyl-diphosphate | 20 kDa BPP hydrolase | Salvia officinalis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | slight stimulation at 10 mM | Salvia officinalis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
20000 | - |
gel filtration, activity on bornyl-diphosphate and bornyl-monophosphate | Salvia officinalis |
65000 | - |
gel filtration | Salvia officinalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-bornyl-diphosphate + H2O | Salvia officinalis | camphor biosynthesis | ? | - |
? | |
geranyl-diphosphate + H2O | Salvia officinalis | acyclic precursor of camphor | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salvia officinalis | - |
sage | - |
Purification (Comment) | Organism |
---|---|
first step: gel filtration, second step: hydroxylapatite chromatography | Salvia officinalis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leaf | - |
Salvia officinalis | - |
Storage Stability | Organism |
---|---|
0°C, 100 mM Tris-maleate pH 7.0, one week, 50% loss of activity for 20 kDa BPP hydrolase | Salvia officinalis |
0°C, 100 mM Tris-maleate pH 7.0, one week, less than 15% loss of activity for 65 kDa BPP hydrolase | Salvia officinalis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-bornyl-diphosphate + H2O | - |
Salvia officinalis | D-borneol + diphosphate | - |
? | |
D-bornyl-diphosphate + H2O | camphor biosynthesis | Salvia officinalis | ? | - |
? | |
D-bornyl-phosphate + H2O | - |
Salvia officinalis | D-borneol + phosphate | - |
? | |
geranyl-diphosphate + H2O | preference for geranyl-ester for 65 kDa BPP hydrolase | Salvia officinalis | geraniol + diphosphate | - |
? | |
geranyl-diphosphate + H2O | acyclic precursor of camphor | Salvia officinalis | ? | - |
? | |
neryl-diphosphate + H2O | - |
Salvia officinalis | nerol + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
pyrophosphate hydrolase | - |
Salvia officinalis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
3.5 | - |
65 kDa BPP hydrolase | Salvia officinalis |
7.6 | - |
20 kDa BPP hydrolase | Salvia officinalis |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
2.5 | 4.5 | 65 kDa BPP hydrolase, 33% of maximum activity above pH 4.5 and below pH 2.5 | Salvia officinalis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.1 | - |
IC50: 0.1 mM for 65 kDa BPP hydrolase, 15.0 mM for 20 kDa BPP hydrolase | Salvia officinalis | Mn2+ | |
0.6 | - |
IC50: 0.6 mM for 65 kDa BPP hydrolase | Salvia officinalis | diphosphate | |
0.7 | - |
IC50: 0.7 mM for 65 kDa BPP hydrolase, 15.5 mM for 20 kDa BPP hydrolase | Salvia officinalis | F- | |
0.8 | - |
IC50: 0.8 mM for 65 kDa BPP hydrolase | Salvia officinalis | diisopropylfluorophosphate | |
2.5 | - |
IC50 2.5 mM for 20 kDa BPP hydrolase | Salvia officinalis | diphosphate | |
10.5 | - |
IC50: 10.5 mM for 65 kDa BPP hydrolase, 4.3 for 20 kDa BPP hydrolase | Salvia officinalis | phosphate |