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Literature summary for 3.1.7.2 extracted from

  • Richter, D.
    Uncharged tRNA inhibits guanosine 3,5-bis (diphosphate) 3-pyrophosphohydrolase [ppGppase], the spoT gene product, from Escherichia coli (1980), Mol. Gen. Genet., 178, 325-327.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Uncharged tRNA
-
Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ activation Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ppGpp + H2O Escherichia coli the substrate functions as a pleiotropic effector restricting metabolic processes such as synthesis of purine nucleotides, glycolytic esters, phospholipids, rRNA, tRNA, mRNA ppG + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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spoT gene product
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ppGpp + H2O i.e. guanosine-3',5'-bis(diphosphate) Escherichia coli ppG + diphosphate i.e. guanosine 5'-diphosphate ?
ppGpp + H2O the substrate functions as a pleiotropic effector restricting metabolic processes such as synthesis of purine nucleotides, glycolytic esters, phospholipids, rRNA, tRNA, mRNA Escherichia coli ppG + diphosphate
-
?