BRENDA - Enzyme Database show
show all sequences of 3.1.6.8

Recognition of arylsulfatase A and B by the UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-phosphotransferase

Yaghootfam, A.; Schestag, F.; Dierks, T.; Gieselmann, V.; J. Biol. Chem. 278, 32653-32661 (2003)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
plasmids containing the wild-type and mutant cDNAs are transiently transfected into BHK cells; wild-type and mutant enzymes transiently transfected into BHK cells
Homo sapiens
Engineering
Amino acid exchange
Commentary
Organism
K302A
34% enzyme activity in comparison to wild-type enzyme; 34% of the activity of wild-type enzyme when expressed in BHK cells. Mutation has no effect on distribution of the enzyme activity between cell and medium
Homo sapiens
K367A
60% enzyme activity in comparison to wild-type enzyme; 60% of the activity of wild-type enzyme when expressed in BHK cells. Mutation has no effect on distribution of the enzyme activity between cell and medium. 106% of the mannose-phosphorylation of the wild-type enzyme
Homo sapiens
K393A
39% enzyme activity in comparison to wild-type enzyme; 39% of the activity of wild-type enzyme when expressed in BHK cells. Mutation has no effect on distribution of the enzyme activity between cell and medium. 123% of the mannose-phosphorylation of the wild-type enzyme
Homo sapiens
K393A/K395G
35% enzyme activity in comparison to wild-type enzyme; 35% of the activity of wild-type enzyme when expressed in BHK cells. Mutation has no effect on distribution of the enzyme activity between cell and medium
Homo sapiens
K393A/K395H
30% enzyme activity in comparison to wild-type enzyme; 30% of the activity of wild-type enzyme when expressed in BHK cells. Mutation has no effect on distribution of the enzyme activity between cell and medium
Homo sapiens
K433A
102% enzyme activity in comparison to wild-type enzyme; 102% of the activity of wild-type enzyme when expressed in BHK cells. Mutation has no effect on distribution of the enzyme activity between cell and medium. 95% of the mannose-phosphorylation of the wild-type enzyme
Homo sapiens
K457G
7.5% enzyme activity in comparison to wild-type enzyme; 7.5% of the activity of wild-type enzyme when expressed in BHK cells. Mutation leads to an increase of enzyme activity in the medium to about 60% of total activity compared to 35% of the wild-type enzyme. 31% of the mannose-phosphorylation of the wild-type enzyme. Mutation affects phosphorylation of oligosaccharide Asn350 to a greater extent than that of oligosaccharide Asn158
Homo sapiens
K457R
45% enzyme activity in comparison to wild-type enzyme; 45% of the activity of wild-type enzyme when expressed in BHK cells. Mutation leads to an increase of enzyme activity in the medium to about 60% of total activity compared to 35% of the wild-type enzyme. 33% of the mannose-phosphorylation of the wild-type enzyme. Mutation affects phosphorylation of oligosaccharide Asn350 to a greater extent than that of oligosaccharide Asn158
Homo sapiens
K457S
25% enzyme activity in comparison to wild-type enzyme; 25% of the activity of wild-type enzyme when expressed in BHK cells. 50% of the mannose-phosphorylation of the wild-type enzyme. Mutation leads to an increase of enzyme activity in the medium to about 65% of total activity compared to 35% of the wild-type enzyme. 50% of the mannose-phosphorylation of the wild-type enzyme. Mutation affects phosphorylation of oligosaccharide Asn350 to a greater extent than that of oligosaccharide Asn158
Homo sapiens
K463Q
14% enzyme activity in comparison to wild-type enzyme; 14% of the activity of wild-type enzyme when expressed in BHK cells. Mutation leads to an decrease of enzyme activity in the medium to about 25% of total activity compared to 35% of the wild-type enzyme
Homo sapiens
K463R
39% enzyme activity in comparison to wild-type enzyme; 39% of the activity of wild-type enzyme when expressed in BHK cells. 31% of the mannose-phosphorylation of the wild-type enzyme. Mutation leads to an decrease of enzyme activity in the medium to about 25% of total activity compared to 35% of the wild-type enzyme
Homo sapiens
additional information
only substitution of Lys457 causes a reduction of phosphorylation to 33% and increases secretion of the mutant enzyme
Homo sapiens
N158Q/N350Q
43% enzyme activity in comparison to wild-type enzyme; 43% of the activity of wild-type enzyme when expressed in BHK cells. Mutation leads to an increase of enzyme activity in the medium to about 25% of total activity compared to 75% of the wild-type enzyme
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
lysosome
-
Homo sapiens
5764
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
glycoprotein
the wild-type enzyme has three N-glycosylation sites. Only oligosaccharides at the first, Asn158, and the third, Asn350, glycosylation site are phosphorylated, whereas the second, Asn184 is not
Homo sapiens
phosphoprotein
compared to the degree of mannose-phosphorylation of the wild-type enzyme, the mutant enzyme K457R has 33%, mutant enzyme K457S has 50%, mutant enzyme K457G has 31%, mutant enzyme K433A has 95%, mutant enzyme K367A has 106% and mutant enzyme K393A has 123% of mannose-phosphorylation respectively
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cerebroside 3-sulfate + H2O
3-O-sulfogalactosyl ceramide
652443
Homo sapiens
cerebroside + sulfate
galactosyl ceramide
-
-
?
cerebroside 3-sulfate + H2O
3-O-sulfogalactosyl ceramide
652443
Homo sapiens
cerebroside + sulfate
galactosyl ceramide
652443
Homo sapiens
?
Cloned(Commentary) (protein specific)
Commentary
Organism
plasmids containing the wild-type and mutant cDNAs are transiently transfected into BHK cells; wild-type and mutant enzymes transiently transfected into BHK cells
Homo sapiens
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
K302A
34% enzyme activity in comparison to wild-type enzyme; 34% of the activity of wild-type enzyme when expressed in BHK cells. Mutation has no effect on distribution of the enzyme activity between cell and medium
Homo sapiens
K367A
60% enzyme activity in comparison to wild-type enzyme; 60% of the activity of wild-type enzyme when expressed in BHK cells. Mutation has no effect on distribution of the enzyme activity between cell and medium. 106% of the mannose-phosphorylation of the wild-type enzyme
Homo sapiens
K393A
39% enzyme activity in comparison to wild-type enzyme; 39% of the activity of wild-type enzyme when expressed in BHK cells. Mutation has no effect on distribution of the enzyme activity between cell and medium. 123% of the mannose-phosphorylation of the wild-type enzyme
Homo sapiens
K393A/K395G
35% enzyme activity in comparison to wild-type enzyme; 35% of the activity of wild-type enzyme when expressed in BHK cells. Mutation has no effect on distribution of the enzyme activity between cell and medium
Homo sapiens
K393A/K395H
30% enzyme activity in comparison to wild-type enzyme; 30% of the activity of wild-type enzyme when expressed in BHK cells. Mutation has no effect on distribution of the enzyme activity between cell and medium
Homo sapiens
K433A
102% enzyme activity in comparison to wild-type enzyme; 102% of the activity of wild-type enzyme when expressed in BHK cells. Mutation has no effect on distribution of the enzyme activity between cell and medium. 95% of the mannose-phosphorylation of the wild-type enzyme
Homo sapiens
K457G
7.5% enzyme activity in comparison to wild-type enzyme; 7.5% of the activity of wild-type enzyme when expressed in BHK cells. Mutation leads to an increase of enzyme activity in the medium to about 60% of total activity compared to 35% of the wild-type enzyme. 31% of the mannose-phosphorylation of the wild-type enzyme. Mutation affects phosphorylation of oligosaccharide Asn350 to a greater extent than that of oligosaccharide Asn158
Homo sapiens
K457R
45% enzyme activity in comparison to wild-type enzyme; 45% of the activity of wild-type enzyme when expressed in BHK cells. Mutation leads to an increase of enzyme activity in the medium to about 60% of total activity compared to 35% of the wild-type enzyme. 33% of the mannose-phosphorylation of the wild-type enzyme. Mutation affects phosphorylation of oligosaccharide Asn350 to a greater extent than that of oligosaccharide Asn158
Homo sapiens
K457S
25% enzyme activity in comparison to wild-type enzyme; 25% of the activity of wild-type enzyme when expressed in BHK cells. 50% of the mannose-phosphorylation of the wild-type enzyme. Mutation leads to an increase of enzyme activity in the medium to about 65% of total activity compared to 35% of the wild-type enzyme. 50% of the mannose-phosphorylation of the wild-type enzyme. Mutation affects phosphorylation of oligosaccharide Asn350 to a greater extent than that of oligosaccharide Asn158
Homo sapiens
K463Q
14% enzyme activity in comparison to wild-type enzyme; 14% of the activity of wild-type enzyme when expressed in BHK cells. Mutation leads to an decrease of enzyme activity in the medium to about 25% of total activity compared to 35% of the wild-type enzyme
Homo sapiens
K463R
39% enzyme activity in comparison to wild-type enzyme; 39% of the activity of wild-type enzyme when expressed in BHK cells. 31% of the mannose-phosphorylation of the wild-type enzyme. Mutation leads to an decrease of enzyme activity in the medium to about 25% of total activity compared to 35% of the wild-type enzyme
Homo sapiens
additional information
only substitution of Lys457 causes a reduction of phosphorylation to 33% and increases secretion of the mutant enzyme
Homo sapiens
N158Q/N350Q
43% enzyme activity in comparison to wild-type enzyme; 43% of the activity of wild-type enzyme when expressed in BHK cells. Mutation leads to an increase of enzyme activity in the medium to about 25% of total activity compared to 75% of the wild-type enzyme
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
lysosome
-
Homo sapiens
5764
-
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
glycoprotein
the wild-type enzyme has three N-glycosylation sites. Only oligosaccharides at the first, Asn158, and the third, Asn350, glycosylation site are phosphorylated, whereas the second, Asn184 is not
Homo sapiens
phosphoprotein
compared to the degree of mannose-phosphorylation of the wild-type enzyme, the mutant enzyme K457R has 33%, mutant enzyme K457S has 50%, mutant enzyme K457G has 31%, mutant enzyme K433A has 95%, mutant enzyme K367A has 106% and mutant enzyme K393A has 123% of mannose-phosphorylation respectively
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cerebroside 3-sulfate + H2O
3-O-sulfogalactosyl ceramide
652443
Homo sapiens
cerebroside + sulfate
galactosyl ceramide
-
-
?
cerebroside 3-sulfate + H2O
3-O-sulfogalactosyl ceramide
652443
Homo sapiens
cerebroside + sulfate
galactosyl ceramide
652443
Homo sapiens
?
Other publictions for EC 3.1.6.8
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
708615
Schroeder
Site-specific analysis of N-li ...
Homo sapiens
Glycobiology
20
248-259
2010
-
1
1
-
-
-
-
-
1
-
1
-
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
714779
Fujita
Mammalian arylsulfatase A func ...
Mus musculus
Connect. Tissue Res.
51
388-396
2010
-
1
1
-
1
-
-
-
1
-
-
1
-
1
-
-
1
-
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
3
3
-
-
-
714958
Poeppel
Misfolded endoplasmic reticulu ...
Homo sapiens
FEBS J.
277
3404-3414
2010
-
-
1
-
8
-
1
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
8
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
3
-
-
-
-
-
-
-
-
-
1
1
-
-
-
691881
Lugowska
Molecular and clinical consequ ...
Homo sapiens
Clin. Genet.
75
57-64
2009
-
1
1
-
3
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
693260
Matzner
Saposin B-dependent reconstitu ...
Homo sapiens
J. Biol. Chem.
284
9372-9381
2009
4
-
1
-
-
-
6
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
1
-
-
-
-
-
4
-
1
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
708623
Schenk
Interaction of arylsulfatase-A ...
Homo sapiens, Sus scrofa
Glycoconj. J.
26
1029-1045
2009
-
-
1
-
2
-
2
-
4
-
-
4
-
2
-
-
-
-
-
4
-
-
12
-
2
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
2
-
-
2
-
-
4
-
-
4
-
-
-
-
-
4
-
-
12
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
708662
Cesani
Characterization of new arylsu ...
Homo sapiens
Hum. Mutat.
30
E936-E945
2009
-
-
1
-
9
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
9
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
692081
Anupriwan
Presence of arylsulfatase A an ...
Mus musculus
Endocrinology
149
3942-3951
2008
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
2
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
675681
Bhattacharyya
Steroid sulfatase, arylsulfata ...
Homo sapiens
J. Steroid Biochem. Mol. Biol.
103
20-34
2007
-
-
-
-
-
-
3
-
-
-
-
-
-
1
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
6
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
680078
Capotondo
Safety of arylsulfatase A over ...
Homo sapiens
Hum. Gene Ther.
18
821-836
2007
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
681035
Wu
Sperm surface arylsulfatase A ...
Mus musculus, Sus scrofa
J. Cell. Physiol.
213
201-211
2007
-
2
-
-
1
-
3
-
-
-
1
-
-
2
-
-
1
-
-
3
3
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
3
-
-
-
-
1
-
-
-
-
1
-
3
3
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667108
Bognar
Kinetics and activity of aryls ...
Homo sapiens
Acta Pharm.
56
95-104
2006
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
3
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
3
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676996
Kasinathan
Tyrosine sulfation of arylsulf ...
Homo sapiens
Protein Pept. Lett.
13
357-361
2006
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677433
Jean
Ethanol decreases rat hepatic ...
Rattus norvegicus
Alcohol. Clin. Exp. Res.
30
1950-1955
2006
-
-
-
-
-
-
2
-
-
-
2
-
-
1
-
-
1
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
1
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
677796
Jimenez
Carbohydrate affinity chromato ...
Sus scrofa
Arch. Androl.
52
455-462
2006
-
-
-
-
-
-
-
-
1
-
3
-
-
2
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668874
Takakusaki
Coexpression of formylglycine- ...
Homo sapiens
Hum. Gene Ther.
16
929-936
2005
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
5
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670343
Luca
Axons mediate the distribution ...
Homo sapiens
Mol. Ther.
12
669-679
2005
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670492
Oner-Iyidogan
Evaluation of leukocyte arylsu ...
Homo sapiens
Pharmacol. Res.
52
340-345
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652538
Heine
Defective endoplasmic reticulu ...
Homo sapiens
J. Biol. Chem.
279
22347-22352
2004
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653357
Yaghootfam
Three novel mutant arylsulfata ...
Homo sapiens
Neurochem. Res.
29
933-942
2004
-
1
1
-
7
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
7
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663938
Christianson
Overexpression of inactive ary ...
Homo sapiens
Biochem. J.
382
581-587
2004
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668313
Sarosiek
Characteristics of arylsulfata ...
Acipenser gueldenstaedtii
Comp. Biochem. Physiol. B
139
571-579
2004
-
-
-
-
-
-
3
5
-
1
1
-
-
1
-
-
-
-
-
1
2
-
1
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
5
-
1
1
-
-
-
-
-
-
1
2
-
1
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
649289
Marcao
-
Biochemical characterization o ...
Homo sapiens
Am. J. Med. Genet.
116A
238-242
2003
-
1
-
-
2
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650506
Weerachatyanukul
Acquisition of arylsulfatase A ...
Mus musculus
Biol. Reprod.
69
1183-1192
2003
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652443
Yaghootfam
Recognition of arylsulfatase A ...
Homo sapiens
J. Biol. Chem.
278
32653-32661
2003
-
-
1
-
13
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
13
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650583
Vagedes
Driving forces of protein asso ...
Homo sapiens
Biophys. J.
83
3066-3078
2002
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
2
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650885
Baldoni
-
Sulfatides and arylsulfatase A ...
Mesocricetus auratus
Comp. Biochem. Physiol. B
131B
787-794
2002
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
651448
Regis
Contribution of arylsulfatase ...
Homo sapiens
Hum. Genet.
110
351-355
2002
-
-
1
-
8
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
8
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
650760
Turkmen
Evaluation of leukocyte arylsu ...
Homo sapiens
Cancer Lett.
166
95-101
2001
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
3
6
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
6
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
652841
von Bulow
Crystal structure of an enzyme ...
Homo sapiens
J. Mol. Biol.
305
269-277
2001
-
-
-
1
2
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
653995
Chen
Lead causes human fibroblasts ...
Homo sapiens
Toxicology
163
107-114
2001
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
649125
Lewinski
-
Crystallization and preliminar ...
Homo sapiens
Acta Crystallogr. Sect. D
56
650-652
2000
-
-
-
1
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
1
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
135692
Lukatela
Crystal structure of human ary ...
Homo sapiens
Biochemistry
37
3654-3664
1998
1
-
1
1
-
-
-
-
-
-
1
1
-
1
-
1
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
1
1
-
-
1
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
135691
Park
Arylsulfatase A: relationship ...
Homo sapiens
Biochem. Genet.
34
149-161
1996
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
135696
Franco
A cluster of sulfatase genes o ...
Homo sapiens
Cell
81
15-25
1995
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
135694
Sommerlade
Glycosylation and phosphorylat ...
Homo sapiens
J. Biol. Chem.
269
20977-20981
1994
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
135511
Wojczyk
Purification of rat liver aryl ...
Rattus norvegicus
Acta Biochim. Pol.
39
355-367
1992
-
-
-
-
-
-
-
-
1
-
1
1
-
1
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
135689
Nikolajczyk
Characterization of rabbit tes ...
Oryctolagus cuniculus
Biol. Reprod.
46
366-378
1992
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
135690
Gadella
Characterization of three aryl ...
Sus scrofa
Biochim. Biophys. Acta
1128
155-162
1992
-
-
-
-
-
-
1
2
-
-
-
1
-
1
-
-
-
-
-
2
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
1
-
-
-
-
-
2
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
135666
Sarafian
-
Large scale purification of py ...
Homo sapiens
J. Appl. Biochem.
4
126-132
1982
-
-
-
-
-
-
-
-
1
-
2
1
-
1
-
1
1
-
-
1
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
1
-
-
1
1
-
1
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
135667
Fluharty
Bile salt activation of cerebr ...
Homo sapiens
Biochem. J.
189
45-49
1980
1
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
135684
Waheed
Chemical characterization and ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
614
92-101
1980
-
-
-
-
-
-
-
6
1
-
1
1
-
1
-
1
1
1
-
1
-
-
10
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
1
-
1
1
-
-
1
1
-
1
-
-
10
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
135679
Roy
The hydrolysis of ascorbate 2- ...
Bos taurus
Methods Enzymol.
62
42-47
1979
-
-
-
-
-
-
-
1
1
-
-
1
-
1
-
-
-
-
-
-
-
-
2
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
-
-
-
2
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
135683
Farooqui
Isolation, characterization an ...
Oryctolagus cuniculus
Biochem. J.
181
331-337
1979
-
1
-
-
-
-
7
-
1
-
-
1
-
1
-
1
1
-
-
1
1
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
7
-
-
1
-
-
1
-
-
1
1
-
1
1
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
135668
Fischer
The activator of cerebroside-s ...
Homo sapiens
Biochim. Biophys. Acta
528
69-76
1978
1
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
135681
Fluharty
Arylsulfatases A and B from hu ...
Homo sapiens
Methods Enzymol.
50
537-547
1978
-
-
-
-
-
1
5
-
1
-
3
1
-
1
-
1
1
1
-
1
-
1
4
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
5
-
-
1
-
3
1
-
-
1
1
-
1
-
1
4
2
1
-
1
-
-
-
-
-
-
-
-
-
-
-
135687
Fischer
Enzymic hydrolysis of sulphosp ...
Homo sapiens
Hoppe-Seyler's Z. Physiol. Chem.
359
863-866
1978
1
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
135682
Helwig
Purification and some properti ...
Oryctolagus cuniculus
Biochem. J.
165
127-134
1977
-
-
-
-
-
-
-
1
1
-
-
1
-
1
-
-
1
1
-
1
1
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
-
1
-
1
1
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
135669
Stevens
Microheterogeneity of arylsulf ...
Homo sapiens
Biochim. Biophys. Acta
445
661-671
1976
-
-
-
-
-
-
-
-
1
-
-
1
-
2
-
1
-
-
-
6
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
-
-
6
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
135671
Mraz
The activator of human cerebro ...
Homo sapiens, Maja squinado, Marthasterias glacialis, Microcosmus sulcatus, Patella vulgata, Tethya aurantium
Hoppe-Seyler's Z. Physiol. Chem.
357
201-206
1976
6
-
-
-
-
-
-
-
1
-
-
6
-
6
-
-
5
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
1
-
-
6
-
-
-
5
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
135672
Mraz
The activator of cerebroside s ...
Homo sapiens, Rattus norvegicus
Hoppe-Seyler's Z. Physiol. Chem.
357
1181-1191
1976
2
-
-
-
-
-
-
-
2
-
-
2
-
2
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
135673
Mraz
Cerebroside sulphatase activit ...
Microcosmus sulcatus, Tethya aurantium
Hoppe-Seyler's Z. Physiol. Chem.
357
1193-1195
1976
2
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
2
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
135695
Roy
Sulphatases, lysosomes and dis ...
Bos taurus, Homo sapiens, Oryctolagus cuniculus
Aust. J. Exp. Biol. Med. Sci.
54
111-135
1976
-
2
-
-
-
-
1
-
-
-
4
3
-
3
-
-
-
-
-
3
-
-
6
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
4
3
-
-
-
-
-
3
-
-
6
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
135670
Fischer
The activator of cerebroside s ...
Homo sapiens
Hoppe-Seyler's Z. Physiol. Chem.
356
605-613
1975
2
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
135676
Stinshoff
Comparison of the cerebroside ...
Homo sapiens
Biochim. Biophys. Acta
377
126-138
1975
6
1
-
-
-
-
7
1
1
-
-
1
-
2
-
-
-
-
-
2
-
-
3
-
-
-
-
-
2
1
-
-
-
-
-
6
1
-
-
-
-
-
-
7
-
1
1
-
-
1
-
-
-
-
-
2
-
-
3
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
135686
Stevens
Purification and properties of ...
Homo sapiens
J. Biol. Chem.
250
2495-2501
1975
1
-
-
-
-
2
-
3
1
1
2
1
-
1
-
-
1
-
-
1
-
3
2
1
-
-
-
3
3
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
3
1
1
2
1
-
-
-
1
-
1
-
3
2
1
-
-
-
3
3
-
-
-
-
-
-
-
-
-
135675
Mraz
Cerebroside sulphatase activit ...
Actinia equina, Blaberus fuscus, Helix pomatia, Limaria tuberculata, Lumbricus terrestris, Marthasterias glacialis, Microcosmus sulcatus, Patella vulgata, Pecten jacobaeus, Tethya aurantium
Hoppe-Seyler's Z. Physiol. Chem.
355
33-44
1974
20
-
-
-
-
-
30
10
-
-
-
10
-
10
-
-
-
10
-
-
-
10
20
-
-
-
2
-
5
-
-
-
-
-
-
20
-
-
-
-
-
-
-
30
-
10
-
-
-
10
-
-
-
-
-
-
-
10
20
-
-
-
2
-
5
-
-
-
-
-
-
-
-
-
135677
Fluharty
Sulfoglycerogalactolipid from ...
Homo sapiens
Biochem. Biophys. Res. Commun.
61
348-354
1974
1
-
-
-
-
-
1
1
1
1
-
1
-
1
-
-
1
-
-
1
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
1
1
1
-
1
-
-
-
1
-
1
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
135674
Jefrey
The sulphatase of ox liver. XV ...
Bos taurus
Biochim. Biophys. Acta
293
178-190
1973
1
-
-
-
-
-
2
1
1
1
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
1
1
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
135678
Porter
Cerebroside sulfatase determin ...
Homo sapiens
Biochim. Biophys. Acta
258
769-778
1972
3
1
-
-
-
-
10
1
-
4
-
1
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
3
1
-
-
-
-
-
-
10
-
1
-
4
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
135685
Farooqui
Purification and properties of ...
Gallus gallus
Biochem. J.
126
1025-1033
1972
-
-
-
-
-
-
9
-
1
-
-
1
-
1
-
-
1
1
-
1
1
1
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
1
-
-
1
-
-
-
1
-
1
1
1
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
135554
Nicholls
-
Arylsulfatases ...
Bos taurus
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
5
21-41
1971
-
-
-
-
-
-
7
12
-
-
-
1
-
1
-
1
-
1
-
-
-
-
13
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
-
12
-
-
-
1
-
-
1
-
-
-
-
-
13
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
135680
Mehl
Cerebroside 3-sulfate as a phy ...
Sus scrofa
Biochim. Biophys. Acta
151
619-627
1968
-
-
-
-
-
-
5
1
1
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
1
1
-
-
1
-
-
-
-
-
1
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-