Literature summary for 3.1.6.4 extracted from

Matassini, C.; Vanni, C.; Goti, A.; Morrone, A.; Marradi, M.; Cardona, F.
Multimerization of DAB-1 onto Au GNPs affords new potent and selective N-acetylgalactosamine-6-sulfatase (GALNS) inhibitors (2018), Org. Biomol. Chem., 16, 8604-8612 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
1,4-dideoxy-1,4-imino-D-arabinitol-gold	gold glyconanoparticles decorated with the natural iminosugar 1,4-dideoxy-1,4-imino-D-arabinitol, i.e. DAB-1 strongly and selectively inhibit N-acetylgalactosamine-6-sulfatase. The strategy employed allowed the enhancement of the multivalent presentation of the iminosugar onto the surface of gold nanoparticles	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P34059	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
leukocyte	-	Homo sapiens	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00052	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	1,4-dideoxy-1,4-imino-D-arabinitol-gold

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Release 2023.1 (January 2023)