Purification and properties of N-acetylgalactosamine 6-sulphate sulphatase from human placenta

Gloessl, J.; Truppe, W.; Kresse, H.; Biochem. J. 181, 37-46 (1979)

Data extracted from this reference:

Activating Compound

Commentary

Organism

Structure

2-mercaptoethanol

activates

Homo sapiens

dithiothreitol

activates

Homo sapiens

EDTA

activates

Homo sapiens

glutathione

activates

Homo sapiens

NEM

activates

Homo sapiens

Inhibitors

Commentary

Organism

Structure

chondroitin 6-sulfate

competitive

Homo sapiens

CN-

-

Homo sapiens

Fe3+

-

Homo sapiens

heparan sulfate

competitive

Homo sapiens

heparin

competitive

Homo sapiens

Hg2+

-

Homo sapiens

K+

-

Homo sapiens

KCl

-

Homo sapiens

Keratan sulfate

competitive

Homo sapiens

Mg2+

-

Homo sapiens

Mn2+

-

Homo sapiens

NaCl

-

Homo sapiens

NO3-

-

Homo sapiens

phosphate

-

Homo sapiens

S2O32-

-

Homo sapiens

SO32-

-

Homo sapiens

SO42-

-

Homo sapiens

Zn2+

-

Homo sapiens

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

Substrate Product ID

N-acetylgalactosamine 6-sulfate-anhydromannitol + H2O

-

135645

Homo sapiens

sulfate + ?

-

-

-

?

Activating Compound

Commentary

Organism

Structure

2-mercaptoethanol

activates

Homo sapiens

dithiothreitol

activates

Homo sapiens

EDTA

activates

Homo sapiens

glutathione

activates

Homo sapiens

NEM

activates

Homo sapiens

Inhibitors

Commentary

Organism

Structure

chondroitin 6-sulfate

competitive

Homo sapiens

CN-

-

Homo sapiens

Fe3+

-

Homo sapiens

heparan sulfate

competitive

Homo sapiens

heparin

competitive

Homo sapiens

Hg2+

-

Homo sapiens

K+

-

Homo sapiens

KCl

-

Homo sapiens

Keratan sulfate

competitive

Homo sapiens

Mg2+

-

Homo sapiens

Mn2+

-

Homo sapiens

NaCl

-

Homo sapiens

NO3-

-

Homo sapiens

phosphate

-

Homo sapiens

S2O32-

-

Homo sapiens

SO32-

-

Homo sapiens

SO42-

-

Homo sapiens

Zn2+

-

Homo sapiens

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

ID

N-acetylgalactosamine 6-sulfate-anhydromannitol + H2O

-

135645

Homo sapiens

sulfate + ?

-

-

-

?

No.

1st author

Pub Med

title

organims

journal

volume

pages

year

Activating Compound

Application

Cloned(Commentary)

Crystallization (Commentary)

Engineering

General Stability

Inhibitors

KM Value [mM]

Localization

Metals/Ions

Molecular Weight [Da]

Natural Substrates/ Products (Substrates)

Organic Solvent Stability

Organism

Oxidation Stability

Posttranslational Modification

Purification (Commentary)

Reaction

Renatured (Commentary)

Source Tissue

Specific Activity [micromol/min/mg]

Storage Stability

Substrates and Products (Substrate)

Subunits

Synonyms

Temperature Optimum [°C]

Temperature Range [°C]

Temperature Stability [°C]

Turnover Number [1/s]

pH Optimum

pH Range

pH Stability

Cofactor

Ki Value [mM]

pI Value

IC50 Value

Activating Compound (protein specific)

Application (protein specific)

Cloned(Commentary) (protein specific)

Cofactor (protein specific)

Crystallization (Commentary) (protein specific)

Engineering (protein specific)

General Stability (protein specific)

IC50 Value (protein specific)

Inhibitors (protein specific)

Ki Value [mM] (protein specific)

KM Value [mM] (protein specific)

Localization (protein specific)

Metals/Ions (protein specific)

Molecular Weight [Da] (protein specific)

Natural Substrates/ Products (Substrates) (protein specific)

Organic Solvent Stability (protein specific)

Oxidation Stability (protein specific)

Posttranslational Modification (protein specific)

Purification (Commentary) (protein specific)

Renatured (Commentary) (protein specific)

Source Tissue (protein specific)

Specific Activity [micromol/min/mg] (protein specific)

Storage Stability (protein specific)

Substrates and Products (Substrate) (protein specific)

Subunits (protein specific)

Temperature Optimum [°C] (protein specific)

Temperature Range [°C] (protein specific)

Temperature Stability [°C] (protein specific)

Turnover Number [1/s] (protein specific)

pH Optimum (protein specific)

pH Range (protein specific)

pH Stability (protein specific)

pI Value (protein specific)

Expression

General Information

General Information (protein specific)

Expression (protein specific)

KCat/KM [mM/s]

KCat/KM [mM/s] (protein specific)

751576

Mashima

Quantification of the enzyme ...

Homo sapiens

Mol. Genet. Metab. Rep.

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Matassini

Multimerization of DAB-1 onto ...

Homo sapiens

Org. Biomol. Chem.

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2018

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Diagnosing mucopolysaccharido ...

Homo sapiens

J. Diabetes Metab. Disord.

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2017

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751772

Bhattacharyya

Chondroitin sulfatases differ ...

Homo sapiens

Oncotarget

8

242-260

2017

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Reyes

Improvement in the production ...

Homo sapiens

Sci. Rep.

7

5844

2017

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749660

Egan

Glycosulfatase-encoding gene ...

Bifidobacterium breve, Bifidobacterium breve UCC2003

Appl. Environ. Microbiol.

82

6611-6623

2016

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Recombinant human N-acetylgal ...

Homo sapiens

Sci. Rep.

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2016

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730284

Feferman

Differential effects of estrog ...

Rattus norvegicus

J. Steroid Biochem. Mol. Biol.

143

105-114

2014

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730366

Olarte-Avellaneda

Computational analysis of huma ...

Homo sapiens

Mol. Biol. Rep.

41

7073-7088

2014

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730183

Hernandez

Effect of culture conditions a ...

Homo sapiens

J. Microbiol. Biotechnol.

23

689-698

2013

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721758

Yang

Exposure to common food additi ...

Homo sapiens

Biochimie

94

1309-1316

2012

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704827

Grinwis

Characterization of Streptococ ...

no activity in Streptococcus anginosus, Streptococcus constellatus, Streptococcus intermedius

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395-401

2010

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Rodriguez

Enzyme replacement therapy for ...

Homo sapiens

J. Ind. Microbiol. Biotechnol.

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2010

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Bhattacharyya

Distinct effects of N-acetylga ...

Homo sapiens

J. Biol. Chem.

283

9523-9530

2008

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Almeciga-Diaz

Effect of elongation factor 1a ...

Homo sapiens

Mol. Biol. Rep.

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1863-1870

2008

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1

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679285

Parkinson-Lawrence

N-acetylgalactosamine-6-sulfat ...

Homo sapiens

Clin. Chim. Acta

377

88-91

2007

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2

1

2

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Tomatsu

Murine model (Galns(tm(C76S)sl ...

Mus musculus

Mol. Genet. Metab.

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251-258

2007

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7

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681958

Tomatsu

Characterization and pharmacok ...

Homo sapiens

Mol. Genet. Metab.

91

69-78

2007

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666376

Laradi

Mucopolysaccharidosis type IV: ...

Homo sapiens

Mol. Genet. Metab.

87

213-218

2006

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2

1

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2

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651462

Tomatsu

Mucopolysaccharidosis IVA (Mor ...

Homo sapiens

Hum. Mutat.

24

187-188

2004

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1

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652762

de Assis

Biosynthesis of chondroitinase ...

Paracoccidioides brasiliensis

J. Med. Microbiol.

52

479-481

2003

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650884

Cechowska-Pasko

Glycosaminoglycan-degrading en ...

Rattus norvegicus

Comp. Biochem. Physiol. B

131

551-557

2002

-

-

-

-

-

-

-

-

-

-

-

-

-

3

-

-

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2

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1

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1

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651460

Terzioglu

Molecular analysis of Turkish ...

Homo sapiens

Hum. Mutat.

20

477-478

2002

-

1

-

-

5

-

-

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2

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1

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1

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651453

Sukegawa

Biochemical and structural ana ...

Homo sapiens

Hum. Mol. Genet.

9

1283-1290

2000

-

1

1

-

17

-

-

-

-

-

3

-

-

2

-

1

-

-

-

-

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2

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1

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1

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6

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1

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-

-

-

-

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7

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1

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2

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1

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3

2

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2

1

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1

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4

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5

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1

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18

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1

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2

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1

1

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Nakanishi

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Nakazawa

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1978

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