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Literature summary for 3.1.6.14 extracted from

  • Freeman, C.; Hopwood, J.J.
    Human liver N-acetylglucosamine-6-sulphate sulphatase. Catalytic properties (1987), Biochem. J., 246, 355-365.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.6.14

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol maximum activity at 0.1 mM Homo sapiens

General Stability

General Stability Organism
bovine serum albumin stabilizes Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bovine serum albumin
-
 Homo sapiens
PO43-
-
 Bos taurus
PO43-
-
 Homo sapiens
SO42-
-
 Bos taurus
SO42-
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0035
-
 O-(alpha-glucosamine 6-sulfate)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate
-
 Homo sapiens
0.0071
-
 N-acetylglucosamine 6-sulfate
-
 Homo sapiens
0.0108
-
 O-(alpha-2-sulfamino glucosamine 6-sulfate)-(1-4)-L-idose
-
 Homo sapiens
0.062
-
 glucose 6-sulfate form A and B Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-D-glucosamine 6-sulfate units + H2O Bos taurus
-
 N-acetyl-D-glucosamine units + sulfate
-
 ?
N-acetyl-D-glucosamine 6-sulfate units + H2O Homo sapiens in oligo-and monosaccharides derived from heparan sulfate and keratan sulfate N-acetyl-D-glucosamine units + sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Homo sapiens
-
kidney
-
 Bos taurus
-
liver
-
 Homo sapiens
-
skin fibroblast in culture Homo sapiens
-
skin fibroblast in culture Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucose 6-sulfate + H2O
-
 Homo sapiens glucose + sulfate
-
 ?
N-acetyl-D-glucosamine 6-sulfate + H2O
-
 Homo sapiens N-acetyl-D-glucosamine + sulfate
-
 ?
N-acetyl-D-glucosamine 6-sulfate units + H2O
-
 Bos taurus N-acetyl-D-glucosamine units + sulfate
-
 ?
N-acetyl-D-glucosamine 6-sulfate units + H2O in substrates bearing a N-acetylglucosamine 6-sulfate residue at its nonreducing terminus derived from heparan sulfate and keratan sulfate Homo sapiens N-acetyl-D-glucosamine units + sulfate
-
 ?
N-acetyl-D-glucosamine 6-sulfate units + H2O specific exosulfatase for desulfation of the nonreducing terminal N-acetylglucosamine 6-sulfate residues of heparansulfate Homo sapiens N-acetyl-D-glucosamine units + sulfate
-
 ?
N-acetyl-D-glucosamine 6-sulfate units + H2O in oligo-and monosaccharides derived from heparan sulfate and keratan sulfate Homo sapiens N-acetyl-D-glucosamine units + sulfate
-
 ?
O-(alpha-2-sulfamino glucosamine 6-sulfate)-(1-4)-L-idonic acid + H2O
-
 Homo sapiens O-(alpha-2-sulfamino glucosamine)-(1-4)-L-idose + sulfate
-
 ?
O-(alpha-2-sulfamino glucosamine 6-sulfate)-(1-4)-L-idose + H2O
-
 Homo sapiens O-(alpha-2-sulfamino glucosamine)-(1-4)-L-idose + sulfate
-
 ?
O-(alpha-glucosamine 6-sulfate)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + H2O
-
 Homo sapiens O-(alpha-glucosamine)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate + sulfate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2 6 depending on substrate structure, overview Homo sapiens
4.3
-
 O-(alpha-glucosamine 6-sulfate)-(1-4)-L-O-(alpha-iduronic acid 2-sulfate)-(1-4)-D-O-2,5-anhydro mannitol 6-sulfate Homo sapiens
4.8
-
 O-(alpha-2-sulfamino glucosamine 6-sulfate)-(1-4)-L-idose Homo sapiens
5.7
-
 glucose 6-sulfate, N-acetylglucosamine 6-sulfate Homo sapiens