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Literature summary for 3.1.6.13 extracted from

  • Lissens, W.; Zenati, A.; Liebaers, I.
    Polyclonal antibodies against iduronate 2-sulphate sulphatase from human urine (1984), Biochim. Biophys. Acta, 801, 365-371.
    View publication on PubMed
Search for more literature for 3.1.6.13

General Stability

General Stability Organism
in water rapid loss of activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
chondroitin 4-sulfate at 0.1 mM Homo sapiens
chondroitin 6-sulfate at 0.1 mM Homo sapiens
Cl-
-
 Homo sapiens
heparan sulfate
-
 Homo sapiens
NaCl due to Cl- Homo sapiens
phosphate
-
 Homo sapiens
SO42- organic sulfates Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0115
-
 O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate pool 1 from urine Homo sapiens
0.013
-
 O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate pool 2 in urine Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
95000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dermatan sulfate + H2O Homo sapiens
-
 dermatan + sulfate
-
 ?
heparan sulfate + H2O Homo sapiens
-
 dermatan + sulfate
-
 ?
heparin + H2O Homo sapiens
-
 desulfated heparin + sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
urine
-
 Homo sapiens
-

Storage Stability

Storage Stability Organism
-20°C, neutral pH, for one year or more Homo sapiens
4°C, pH 7.2, 150 mM NaCl, several days Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dermatan sulfate + H2O
-
 Homo sapiens dermatan + sulfate
-
 ?
heparan sulfate + H2O
-
 Homo sapiens dermatan + sulfate
-
 ?
heparin + H2O
-
 Homo sapiens desulfated heparin + sulfate
-
 ?
O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + H2O
-
 Homo sapiens O-(alpha-L-idopyranosyluronic acid)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + sulfate
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
 stable for 10 min Homo sapiens
75
-
 2 min, complete loss of activity Homo sapiens