Literature summary for 3.1.6.12 extracted from

Bhattacharyya, S.; Feferman, L.; Tobacman, J.K.
Effect of CFTR modifiers on arylsulfatase B activity in cystic fibrosis and normal human bronchial epithelial cells (2016), Pulm. Pharmacol. Ther., 36, 22-30 .

Search for more literature for 3.1.6.12

Application

Application	Comment	Organism
medicine	ARSB is reduced in cystic fibrosis cells and increases when defective cystic fibrosis transmembrane conductance regulator CFTR is repaired. The CFTR potentiator VRT-532 increases ARSB activity and expression to the level in normal bronchial epithelial cells. Concomitantly, total sulfated glycosaminoglycans and chondroitin 4-sulfate decline, secreted interleukin IL-8 increases, secreted IL-6 declines, and neutrophil chemotaxis to the spent media obtained from the potentiator-treated cystic fibrosis cells increases	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15848	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epithelial cell	bronchial epithelial cell	Homo sapiens	-

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Release 2023.1 (January 2023)