Literature summary for 3.1.6.12 extracted from

Bhattacharyya, S.; Feferman, L.; Tobacman, J.
Inhibition of phosphatase activity follows decline in sulfatase activity and leads to transcriptional effects through sustained phosphorylation of transcription factor MITF (2016), PLoS ONE, 11, e0153463 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15848	-	-
Mus musculus	P50429	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-
liver	-	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	a decline in ARSB activity increases transmembrane glycoprotein NMB expression. Protein tyrosine phosphatase SHP2 activity declines due to increased binding with chondroitin 4-sulfate when ARSB is reduced. When SHP2 activity is inhibited, phosphorylations of p38 mitogen-associated phosphokinase and of microphthalmia-associated transcription factor increase, leading to transmembrane glycoprotein NMB promoter activation. In contrast, constitutively active SHP2 and overexpression of ARSB inhibit NMB expression	Homo sapiens
physiological function	a decline in ARSB activity increases transmembrane glycoprotein NMB expression. Protein tyrosine phosphatase SHP2 activity declines due to increased binding with chondroitin 4-sulfate when ARSB is reduced. When SHP2 activity is inhibited, phosphorylations of p38 mitogen-associated phosphokinase and of microphthalmia-associated transcription factor increase, leading to transmembrane glycoprotein NMB promoter activation. In contrast, constitutively active SHP2 and overexpression of ARSB inhibit NMB expression	Mus musculus

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Release 2023.1 (January 2023)