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Literature summary for 3.1.6.12 extracted from

  • Zhang, X.; Bhattacharyya, S.; Kusumo, H.; Goodlett, C.R.; Tobacman, J.K.; Guizzetti, M.
    Arylsulfatase B modulates neurite outgrowth via astrocyte chondroitin-4-sulfate: dysregulation by ethanol (2014), Glia, 62, 259-271.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
ethanol astrocyte treatment with ethanol inhibits the activity of arylsulfatase B, and triggers the degradation of chondroitin-4-sulfate, increases total sulfated glycosaminoglycans, chondroitin-4-sulfate and neurocan core-protein content and inhibits neurite outgrowth in neurons cocultured with ethanol-treated astrocytes in vitro. Ethanol also inhibits arylsulfatase B activity and increases sulfated glycosaminoglycans and neurocan levels in the developing hippocampus after in vivo ethanol exposure Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P50430
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Rattus norvegicus
-
hippocampus
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
ARSB
-
 Rattus norvegicus
arylsulfatase B
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function astrocyte treatment with ethanol inhibits the activity of arylsulfatase B, and triggers the degradation of chondroitin-4-sulfate, increases total sulfated glycosaminoglycans, chondroitin-4-sulfate and neurocan core-protein content and inhibits neurite outgrowth in neurons cocultured with ethanol-treated astrocytes in vitro. Ethanol also inhibits arylsulfatase B activity and increases sulfated glycosaminoglycans and neurocan levels in the developing hippocampus after in vivo ethanol exposure. Arylsulfatase B silencing increases the levels of sulfated glycosaminoglycans, chondroitin-4-sulfate, and neurocan in astrocytes and inhibits neurite outgrowth in cocultured neurons Rattus norvegicus