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Literature summary for 3.1.6.12 extracted from

  • Prabhu, S.V.; Bhattacharyya, S.; Guzman-Hartman, G.; Macias, V.; Kajdacsy-Balla, A.; Tobacman, J.K.
    Extra-lysosomal localization of arylsulfatase B in human colonic epithelium (2011), J. Histochem. Cytochem., 59, 328-335.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
diagnostics altered ARSB immunostaining and reduced activity may be useful indicators of malignant transformation in human colonic tissue Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell membrane
-
Homo sapiens
-
-
additional information extra-lysosomal enzyme localization Homo sapiens
-
-
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
chondroitin-4-sulfate + H2O Homo sapiens arylsulfatase B removes 4-sulfate groups from the sulfated glycosaminoglycans chondroitin-4-sulfate and dermatan sulfate chondroitin + sulfate
-
?
dermatan sulfate + H2O Homo sapiens arylsulfatase B removes 4-sulfate groups from the sulfated glycosaminoglycans chondroitin-4-sulfate and dermatan sulfate dermatan + sulfate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adenocarcinoma cell ARSB enzymatic activity is significantly greater in normal than in malignant tissue Homo sapiens
-
adenoma cell ARSB enzymatic activity is significantly greater in normal than in malignant tissue Homo sapiens
-
bronchial epithelium
-
Homo sapiens
-
cerebrovascular cell
-
Homo sapiens
-
colon
-
Homo sapiens
-
colonic adenocarcinoma cell
-
Homo sapiens
-
colonic adenoma cell
-
Homo sapiens
-
colonic epithelium
-
Homo sapiens
-
colonic epithelium ARSB enzymatic activity is significantly greater in normal than in malignant tissue Homo sapiens
-
hepatocyte
-
Homo sapiens
-
additional information differences in distribution, intensity, and pattern of ARSB staining among normal colon, adenomas, and adenocarcinomas, overview. Distinctive, intense luminal membrane staining is present in the normal epithelial cells but reduced in the malignancies and less in the grade 3 than in the grade 1 adenocarcinomas. ARSB enzymatic activity is significantly greater in normal than in malignant tissue, detailed overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
chondroitin-4-sulfate + H2O arylsulfatase B removes 4-sulfate groups from the sulfated glycosaminoglycans chondroitin-4-sulfate and dermatan sulfate Homo sapiens chondroitin + sulfate
-
?
dermatan sulfate + H2O arylsulfatase B removes 4-sulfate groups from the sulfated glycosaminoglycans chondroitin-4-sulfate and dermatan sulfate Homo sapiens dermatan + sulfate
-
?

Synonyms

Synonyms Comment Organism
ARSB
-
Homo sapiens
arylsulfatase B
-
Homo sapiens
ASB
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens differences in distribution, intensity, and pattern of ARSB staining among normal colon, adenomas, and adenocarcinomas is shown. Distinctive, intense luminal membrane staining is present in the normal epithelial cells but reduced in the malignancies and less in the grade 3 than in the grade 1 adenocarcinomas. In the normal cores, a distinctive pattern of intense cytoplasmic positivity at the luminal surface is followed by reduced staining deeper in the crypts additional information

General Information

General Information Comment Organism
malfunction ARSB enzymatic activity is significantly greater in normal than in malignant tissue Homo sapiens
malfunction inborn deficiency of ARSB leads to the lysosomal storage disease mucopolysaccharidosis VI, characterized by accumulation of sulfated glycosaminoglycans in vital organs, disruption of normal physiological processes, severe morbidity, and premature death Homo sapiens
physiological function arylsulfatase B removes 4-sulfate groups from the sulfated glycosaminoglycans chondroitin-4-sulfate and dermatan sulfate Homo sapiens