Application | Comment | Organism |
---|---|---|
diagnostics | altered ARSB immunostaining and reduced activity may be useful indicators of malignant transformation in human colonic tissue | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell membrane | - |
Homo sapiens | - |
- |
additional information | extra-lysosomal enzyme localization | Homo sapiens | - |
- |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
chondroitin-4-sulfate + H2O | Homo sapiens | arylsulfatase B removes 4-sulfate groups from the sulfated glycosaminoglycans chondroitin-4-sulfate and dermatan sulfate | chondroitin + sulfate | - |
? | |
dermatan sulfate + H2O | Homo sapiens | arylsulfatase B removes 4-sulfate groups from the sulfated glycosaminoglycans chondroitin-4-sulfate and dermatan sulfate | dermatan + sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adenocarcinoma cell | ARSB enzymatic activity is significantly greater in normal than in malignant tissue | Homo sapiens | - |
adenoma cell | ARSB enzymatic activity is significantly greater in normal than in malignant tissue | Homo sapiens | - |
bronchial epithelium | - |
Homo sapiens | - |
cerebrovascular cell | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
colonic adenocarcinoma cell | - |
Homo sapiens | - |
colonic adenoma cell | - |
Homo sapiens | - |
colonic epithelium | - |
Homo sapiens | - |
colonic epithelium | ARSB enzymatic activity is significantly greater in normal than in malignant tissue | Homo sapiens | - |
hepatocyte | - |
Homo sapiens | - |
additional information | differences in distribution, intensity, and pattern of ARSB staining among normal colon, adenomas, and adenocarcinomas, overview. Distinctive, intense luminal membrane staining is present in the normal epithelial cells but reduced in the malignancies and less in the grade 3 than in the grade 1 adenocarcinomas. ARSB enzymatic activity is significantly greater in normal than in malignant tissue, detailed overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
chondroitin-4-sulfate + H2O | arylsulfatase B removes 4-sulfate groups from the sulfated glycosaminoglycans chondroitin-4-sulfate and dermatan sulfate | Homo sapiens | chondroitin + sulfate | - |
? | |
dermatan sulfate + H2O | arylsulfatase B removes 4-sulfate groups from the sulfated glycosaminoglycans chondroitin-4-sulfate and dermatan sulfate | Homo sapiens | dermatan + sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ARSB | - |
Homo sapiens |
arylsulfatase B | - |
Homo sapiens |
ASB | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | differences in distribution, intensity, and pattern of ARSB staining among normal colon, adenomas, and adenocarcinomas is shown. Distinctive, intense luminal membrane staining is present in the normal epithelial cells but reduced in the malignancies and less in the grade 3 than in the grade 1 adenocarcinomas. In the normal cores, a distinctive pattern of intense cytoplasmic positivity at the luminal surface is followed by reduced staining deeper in the crypts | additional information |
General Information | Comment | Organism |
---|---|---|
malfunction | ARSB enzymatic activity is significantly greater in normal than in malignant tissue | Homo sapiens |
malfunction | inborn deficiency of ARSB leads to the lysosomal storage disease mucopolysaccharidosis VI, characterized by accumulation of sulfated glycosaminoglycans in vital organs, disruption of normal physiological processes, severe morbidity, and premature death | Homo sapiens |
physiological function | arylsulfatase B removes 4-sulfate groups from the sulfated glycosaminoglycans chondroitin-4-sulfate and dermatan sulfate | Homo sapiens |