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Literature summary for 3.1.6.12 extracted from

  • Bhattacharyya, S.; Kotlo, K.; Shukla, S.; Danziger, R.S.; Tobacman, J.K.
    Distinct effects of N-acetylgalactosamine-4-sulfatase and galactose-6-sulfatase expression on chondroitin sulfates (2008), J. Biol. Chem., 283, 9523-9530.
    View publication on PubMed
Search for more literature for 3.1.6.12

Cloned(Commentary)

Cloned (Comment) Organism
expression in MCF-7 cells Homo sapiens
expression in MCF-7 cells. Following overexpression of the enzyme, total sulfated glycosaminoglycans, chondroitin 4-sulfate, and chondroitin sulfates declines significantly Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P15848
-
-
Homo sapiens P15848 precursor
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferyl sulfate + H2O
-
 Homo sapiens 4-methylumbelliferone + sulfate
-
 ?
4-methylumbelliferyl sulfate + H2O
-
 Homo sapiens sulfate + 4-methylumbelliferone
-
 ?
chondroitin 4-sulfate + H2O
-
 Homo sapiens chondroitin + sulfate
-
 ?
chondroitin sulfate + H2O
-
 Homo sapiens chondroitin + sulfate
-
 ?
dermatan sulfate + H2O
-
 Homo sapiens dermatan + sulfate
-
 ?
sulfated glycosaminoglycan + H2O
-
 Homo sapiens glycosaminoglycan + sulfate
-
 ?

Synonyms

Synonyms Comment Organism
arylsulfatase B
-
 Homo sapiens
ASB
-
 Homo sapiens
N-acetylgalactosamine-4-sulfatase
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction deficiencies of N-acetylgalactosamine-4-sulfatase is associated with the mucopolysaccharidoses Homo sapiens
metabolism modification of expression of the enzyme regulates the content of chondroitin sulfate Homo sapiens