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Literature summary for 3.1.6.12 extracted from
- Immunochemical characterization of feline and human N-acetylgalactosamine 4-sulfatase (1994), Biochem. Med. Metab. Biol., 53, 58-66.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme replacement in MPS IV feline fibroblast | Homo sapiens |
| medicine | enzyme replacement in MPS IV feline fibroblast | Felis catus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in CHO cells | Felis catus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 13000 | - |
1 * 57000, composed of 2 peptides 1 * 43000, 1 * 13000 | Homo sapiens |
| 43000 | - |
gel filtration, SDS-PAGE | Homo sapiens |
| 43000 | - |
gel filtration, SDS-PAGE | Felis catus |
| 43000 | - |
under reducing conditions | Homo sapiens |
| 43000 | - |
under reducing conditions | Felis catus |
| 57000 | - |
1 * 57000, composed of 2 peptides 1 * 43000, 1 * 13000 | Homo sapiens |
| 57000 | 61000 | diffuse band, unreduced PAGE | Homo sapiens |
| 57000 | 61000 | diffuse band, unreduced PAGE | Felis catus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-acetyl-D-galactosamine 4-sulfate units + H2O | Homo sapiens | acts also on N-acetylglucosamine 4-sulfate | N-acetyl-D-galactosamine units + sulfate | - |
? |  |
| N-acetyl-D-galactosamine 4-sulfate units + H2O | Felis catus | acts also on N-acetylglucosamine 4-sulfate | N-acetyl-D-galactosamine units + sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Felis catus | - |
siamese cat, feline model of human Maroteaux-Lamy Syndrom | - |
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Felis catus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Felis catus | - |
| fibroblast | in culture | Felis catus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Felis catus | - |
| leukocyte | - |
Felis catus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Felis catus | - |
| spleen | - |
Felis catus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferyl sulfate + H2O | - |
Homo sapiens | 4-methylumbelliferone + sulfate | - |
? | |
| 4-methylumbelliferyl sulfate + H2O | - |
Felis catus | 4-methylumbelliferone + sulfate | - |
? | |
| N-acetyl-D-galactosamine 4-sulfate units + H2O | acts also on N-acetylglucosamine 4-sulfate | Homo sapiens | N-acetyl-D-galactosamine units + sulfate | - |
? | |
| N-acetyl-D-galactosamine 4-sulfate units + H2O | acts also on N-acetylglucosamine 4-sulfate | Felis catus | N-acetyl-D-galactosamine units + sulfate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Felis catus |
| monomer | 1 * 57000, composed of 2 peptides 1 * 43000, 1 * 13000 | Homo sapiens |
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