Literature summary for 3.1.5.B1 extracted from

Bhattacharya, A.; Wang, Z.; White, T.; Buffone, C.; Nguyen, L.A.; Shepard, C.N.; Kim, B.; Demeler, B.; Diaz-Griffero, F.; Ivanov, D.N.
Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect (2016), Sci. Rep., 6, 31353 .

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D311A	mutation which removes one of the metal coordination residues in the active site and results in the loss of dNTPase activity	Homo sapiens
T592D	mutant affects kinetics of tetramer assembly and disassembly, but its effects on tetramerization equilibrium and dNTPase activity are insignificant	Homo sapiens
Y146S/Y154S	dimerization-defective mutant, displays a severe dNTPase defect in vitro, but is indistinguishable from wild-type in its ability to deplete cellular dNTP pools and to restrict HIV replication	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y3Z3	-	-

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Release 2023.1 (January 2023)