Literature summary for 3.1.5.B1 extracted from

Seamon, K.J.; Stivers, J.T.
A high-throughput enzyme-coupled assay for SAMHD1 dNTPase (2015), J. Biomol. Screen., 20, 801-809 .

Search for more literature for 3.1.5.B1

Application

Application	Comment	Organism
analysis	high-throughput colorimetric assay for dNTP hydrolase activity, using Escherichia coli inorganic pyrophosphatase to convert triphosphate to 3 phosphates	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
acycloguanosine	-	Homo sapiens
cephalosporin C	zinc salt, inhibition is largely attributable to zinc	Homo sapiens
Zn2+	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y3Z3	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0011	-	pH 7.5, temperature not specified in the publication	Homo sapiens	cephalosporin C
0.0021	-	pH 7.5, temperature not specified in the publication	Homo sapiens	Zn2+
0.764	-	pH 7.5, temperature not specified in the publication	Homo sapiens	acycloguanosine

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Release 2023.1 (January 2023)