Crystallization (Comment) | Organism |
---|---|
structures of variants T592E and T592V. Mutation T592E induces large conformational changes, likely triggered by electrostatic repulsion from a distinct negatively charged environment surrounding residue Thr-592 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
T592E | phosphomimetic mutation, reduces the stability of the SAMHD1 tetramer. about 3fold decrease in activity | Homo sapiens |
T592V | neutral substitution, does not perturb the structure | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y3Z3 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dATP + H2O | - |
Homo sapiens | deoxyadenosine + triphosphate | - |
? |