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Literature summary for 3.1.5.B1 extracted from

  • Franzolin, E.; Pontarin, G.; Rampazzo, C.; Miazzi, C.; Ferraro, P.; Palumbo, E.; Reichard, P.; Bianchi, V.
    The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells (2013), Proc. Natl. Acad. Sci. USA, 110, 14272-14277.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.5.B1

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y3Z3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
SAMHD1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme is variably expressed during the cell cycle, maximally during quiescence and minimally during S-phase additional information

General Information

General Information Comment Organism
physiological function treatment of lung or skin fibroblasts with enzyme-specific siRNA results in the disappearence of enzyme protein accompanied by loss of the cell-cycle regulation of dNTP pool sizes and dNTP imbalance. Cells accumulate in G1 phase with oversized pools and stopp growing. Following removal of the siRNA, the pools are normalized and cell growth restarted, but only after enzyme SAMHD1 has reappeared. In quiescent cultures SAMHD1 down-regulation leads to a marked expansion of dNTP pools. In all cases the largest effect was on dGTP, the preferred substrate of SAMHD1 Homo sapiens