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Literature summary for 3.1.5.1 extracted from

  • Itsko, M.; Schaaper, R.M.
    The dgt gene of Escherichia coli facilitates thymine utilization in thymine-requiring strains (2011), Mol. Microbiol., 81, 1221-1232.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.5.1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dGTP + H2O Escherichia coli
-
 deoxyguanosine + triphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 gene dgt
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dGTP + H2O
-
 Escherichia coli deoxyguanosine + triphosphate
-
 ?

Synonyms

Synonyms Comment Organism
dGTP triphosphohydrolase
-
 Escherichia coli
dGTPase
-
 Escherichia coli

General Information

General Information Comment Organism
metabolism blockage of the alternative dUMP phosphatase pathway for deoxyribose-1-phosphate generation greatly exacerbates the severity of thymine starvation in enriched media, and under these conditions the dgt pathway becomes crucial in protecting the cells against thymineless death Escherichia coli
physiological function the minimal amount of thymine required for growth of thymine-requiring (thyA) strains decreases with increased expression level of the dgt gene. As expected, this dgt-mediated effect is dependent on the DeoD purine nucleoside phosphorylase. ThyA strains experience growth difficulties upon nutritional shift-up, the dgt gene facilitates adaptation to the new growth conditions Escherichia coli