Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dGTP + H2O | Escherichia coli | - |
deoxyguanosine + triphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
gene dgt | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dGTP + H2O | - |
Escherichia coli | deoxyguanosine + triphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dGTP triphosphohydrolase | - |
Escherichia coli |
dGTPase | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
metabolism | blockage of the alternative dUMP phosphatase pathway for deoxyribose-1-phosphate generation greatly exacerbates the severity of thymine starvation in enriched media, and under these conditions the dgt pathway becomes crucial in protecting the cells against thymineless death | Escherichia coli |
physiological function | the minimal amount of thymine required for growth of thymine-requiring (thyA) strains decreases with increased expression level of the dgt gene. As expected, this dgt-mediated effect is dependent on the DeoD purine nucleoside phosphorylase. ThyA strains experience growth difficulties upon nutritional shift-up, the dgt gene facilitates adaptation to the new growth conditions | Escherichia coli |