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Literature summary for 3.1.4.61 extracted from

  • van Alebeek, G.; Tafazzul, G.; Kreuwels, M.; Keltjens, J.; Vogels, G.
    Cyclic 2,3-diphosphoglycerate metabolism in Methanobacterium thermoautotrophicum (strain DELTAH) characterization of the synthetase reaction (1994), Arch. Microbiol., 162, 193-198 .
No PubMed abstract available
Search for more literature for 3.1.4.61

Activating Compound

Activating Compound Comment Organism Structure
additional information activation of the cDPG hydrolase is required in contrast to the cDPG synthase Methanothermobacter thermautotrophicus

Inhibitors

Inhibitors Comment Organism Structure
K+ at high concentrations Methanothermobacter thermautotrophicus
O2
-
 Methanothermobacter thermautotrophicus
phosphate
-
 Methanothermobacter thermautotrophicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane bound Methanothermobacter thermautotrophicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ required for activation Methanothermobacter thermautotrophicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cyclic 2,3-bisphosphoglycerate + H2O Methanothermobacter thermautotrophicus
-
 2,3-diphosphoglycerate
-
 ?
cyclic 2,3-bisphosphoglycerate + H2O Methanothermobacter thermautotrophicus DSM 1053
-
 2,3-diphosphoglycerate
-
 ?
cyclic 2,3-bisphosphoglycerate + H2O Methanothermobacter thermautotrophicus DELTAH
-
 2,3-diphosphoglycerate
-
 ?

Organism

Organism UniProt Comment Textmining
Methanothermobacter thermautotrophicus
-
-
-
Methanothermobacter thermautotrophicus DELTAH
-
-
-
Methanothermobacter thermautotrophicus DSM 1053
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclic 2,3-bisphosphoglycerate + H2O
-
 Methanothermobacter thermautotrophicus 2,3-diphosphoglycerate
-
 ?
cyclic 2,3-bisphosphoglycerate + H2O
-
 Methanothermobacter thermautotrophicus DSM 1053 2,3-diphosphoglycerate
-
 ?
cyclic 2,3-bisphosphoglycerate + H2O
-
 Methanothermobacter thermautotrophicus DELTAH 2,3-diphosphoglycerate
-
 ?

Synonyms

Synonyms Comment Organism
cDPG hydrolase
-
 Methanothermobacter thermautotrophicus

General Information

General Information Comment Organism
metabolism cDPG synthesis and hydrolysis in methanogenic bacteria are catalyzed by two different enzymes: cyclic 2,3-diphosphoglycerate (cDPG) synthetase and cDPG hydrolase. The hydrolase catalyzes the hydrolysis of cyclic 2,3-bisphosphoglycerate to 2,3-diphosphoglycerate. The reverse reaction is catalyzed by cDPG synthetase in an ATP-dependent manner. The routes of cDPG biosynthesis and degradation are interconnected Methanothermobacter thermautotrophicus