BRENDA - Enzyme Database
show all sequences of 3.1.4.60

New insights into the cyclic di-adenosine monophosphate (c-di-AMP) degradation pathway and the requirement of the cyclic dinucleotide for acid stress resistance in Staphylococcus aureus

Bowman, L.; Zeden, M.S.; Schuster, C.F.; Kaever, V.; Gruendling, A.; J. Biol. Chem. 291, 26970-26986 (2016)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
ppGpp
-
Staphylococcus aureus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O
Staphylococcus aureus
-
2 AMP
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Staphylococcus aureus
A0A0H2XFX6
USA300
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O
-
751077
Staphylococcus aureus
2 AMP
-
-
-
?
additional information
Pde2 is capable of hydrolyzing c-di-AMP, but5 preferentially converts linear 5'-phosphadenylyl-adenosine (pApA) to AMP. No substrate: ATP
751077
Staphylococcus aureus
?
-
-
-
-
additional information
Pde2 is capable of hydrolyzing c-di-AMP, but5 preferentially converts linear 5'-phosphadenylyl-adenosine (pApA) to AMP. No substrate: ATP
751077
Staphylococcus aureus USA300
?
-
-
-
-
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
ppGpp
-
Staphylococcus aureus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O
Staphylococcus aureus
-
2 AMP
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O
-
751077
Staphylococcus aureus
2 AMP
-
-
-
?
additional information
Pde2 is capable of hydrolyzing c-di-AMP, but5 preferentially converts linear 5'-phosphadenylyl-adenosine (pApA) to AMP. No substrate: ATP
751077
Staphylococcus aureus
?
-
-
-
-
additional information
Pde2 is capable of hydrolyzing c-di-AMP, but5 preferentially converts linear 5'-phosphadenylyl-adenosine (pApA) to AMP. No substrate: ATP
751077
Staphylococcus aureus USA300
?
-
-
-
-
General Information
General Information
Commentary
Organism
physiological function
a Pde2 mutant strain displays a growth defect in the early growth phase. The mutant displays an increase in cellular c-di-AMP and 5'-O-phosphonoadenylyl-(3'->5')-adenosine levels and increased oxacillin resistance. A strain producing a high level of c-di-AMP has increased and a stain producing low levels has decreased acid resistance
Staphylococcus aureus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
a Pde2 mutant strain displays a growth defect in the early growth phase. The mutant displays an increase in cellular c-di-AMP and 5'-O-phosphonoadenylyl-(3'->5')-adenosine levels and increased oxacillin resistance. A strain producing a high level of c-di-AMP has increased and a stain producing low levels has decreased acid resistance
Staphylococcus aureus
Other publictions for EC 3.1.4.60
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
751077
Bowman
New insights into the cyclic ...
Staphylococcus aureus
J. Biol. Chem.
291
26970-26986
2016
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
750844
Tang
Functional analysis of a c-di ...
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis ATCC 700084
Int. J. Biol. Sci.
11
813-824
2015
-
-
-
-
2
-
-
-
-
4
-
4
-
2
-
-
-
-
-
-
-
-
4
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
4
-
4
-
-
-
-
-
-
-
-
4
-
2
-
-
-
1
-
-
-
-
1
1
-
-
-
750731
Ye
DhhP, a cyclic di-AMP phospho ...
Borreliella burgdorferi, Borreliella burgdorferi DSM 4680
Infect. Immun.
82
1840-1849
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
750954
Bai
Two DHH subfamily 1 proteins ...
Streptococcus pneumoniae serotype 2, Streptococcus pneumoniae serotype 2 D39
J. Bacteriol.
195
5123-5132
2013
-
-
-
-
-
-
-
1
1
1
-
-
-
2
-
-
-
-
-
-
-
-
5
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
5
2
-
-
-
-
1
-
-
-
-
1
1
-
-
-