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Literature summary for 3.1.4.59 extracted from

  • Cabezas, A.; Costas, M.J.; Canales, J.; Pinto, R.M.; Rodrigues, J.R.; Ribeiro, J.M.; Cameselle, J.C.
    Enzyme characterization of pro-virulent SntA, a cell wall-anchored protein of Streptococcus suis, with phosphodiesterase activity on cyclic-di-AMP at a level suited to limit the innate immune system (2022), Front. Microbiol., 13, 843068.
    View publication on PubMed
Search for more literature for 3.1.4.59

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptococcus suis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00077
-
 c-di-GMP pH 7.5, 37°C Streptococcus suis
0.001
-
 3',3'-cGAMP pH 7.5, 37°C Streptococcus suis
0.00199
-
 pGpG pH 7.5, 37°C Streptococcus suis
0.00262
-
 3'-AMP pH 7.5, 37°C Streptococcus suis
0.00266
-
 cyclic di-3',5'-adenylate pH 7.5, 37°C Streptococcus suis
0.00286
-
 PapA pH 7.5, 37°C Streptococcus suis
0.00397
-
 2',3'-cAMP pH 7.5, 37°C Streptococcus suis
0.00405
-
 3'-GMP pH 7.5, 37°C Streptococcus suis
0.0165
-
 2',3'-cGMP pH 7.5, 37°C Streptococcus suis
0.02042
-
 3'-UMP pH 7.5, 37°C Streptococcus suis
0.02051
-
 2',3'-cGAMP pH 7.5, 37°C Streptococcus suis
0.03675
-
 2',3'-cCMP pH 7.5, 37°C Streptococcus suis
0.04052
-
 Ap4A pH 7.5, 37°C Streptococcus suis
0.06245
-
 Ap3A pH 7.5, 37°C Streptococcus suis
0.0927
-
 ATP pH 7.5, 37°C Streptococcus suis
0.1085
-
 ADP pH 7.5, 37°C Streptococcus suis
0.15498
-
 ADP-ribose pH 7.5, 37°C Streptococcus suis
0.20804
-
 2',3'-cUMP pH 7.5, 37°C Streptococcus suis
0.40657
-
 bis-4NPhP pH 7.5, 37°C Streptococcus suis
2.68
-
 4-NPhP pH 7.5, 37°C Streptococcus suis

Organism

Organism UniProt Comment Textmining
Streptococcus suis Q8VUN9 cf. EC 3.1.4.16
-
Streptococcus suis CCUG 7984 Q8VUN9 cf. EC 3.1.4.16
-

Purification (Commentary)

Purification (Comment) Organism
-
 Streptococcus suis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2',3'-cAMP + H2O
-
 Streptococcus suis ?
-
 ?
2',3'-cAMP + H2O
-
 Streptococcus suis CCUG 7984 ?
-
 ?
2',3'-cCMP + H2O
-
 Streptococcus suis ?
-
 ?
2',3'-cGAMP + H2O
-
 Streptococcus suis ?
-
 ?
2',3'-cGMP + H2O
-
 Streptococcus suis ?
-
 ?
2',3'-cUMP + H2O
-
 Streptococcus suis ?
-
 ?
3',3'-cGAMP + H2O
-
 Streptococcus suis ?
-
 ?
3'-AMP + H2O
-
 Streptococcus suis ?
-
 ?
3'-AMP + H2O
-
 Streptococcus suis CCUG 7984 ?
-
 ?
3'-GMP + H2O
-
 Streptococcus suis ?
-
 ?
3'-GMP + H2O
-
 Streptococcus suis CCUG 7984 ?
-
 ?
3'-UMP + H2O
-
 Streptococcus suis ?
-
 ?
3'-UMP + H2O
-
 Streptococcus suis CCUG 7984 ?
-
 ?
4-NPhP + H2O
-
 Streptococcus suis ?
-
 ?
ADP + H2O
-
 Streptococcus suis ?
-
 ?
ADP-ribose + H2O
-
 Streptococcus suis ?
-
 ?
Ap3A + H2O
-
 Streptococcus suis ?
-
 ?
Ap4A + H2O
-
 Streptococcus suis ?
-
 ?
ATP + H2O
-
 Streptococcus suis ?
-
 ?
bis-4NPhP + H2O
-
 Streptococcus suis ?
-
 ?
c-di-AMP + H2O
-
 Streptococcus suis ?
-
 ?
c-di-GMP + H2O
-
 Streptococcus suis ?
-
 ?
cyclic di-3',5'-adenylate + H2O
-
 Streptococcus suis 5'-O-phosphonoadenylyl-(3'->5')-adenosine
-
 ?
cyclic di-3',5'-adenylate + H2O
-
 Streptococcus suis CCUG 7984 5'-O-phosphonoadenylyl-(3'->5')-adenosine
-
 ?
PapA + H2O
-
 Streptococcus suis ?
-
 ?
pGpG + H2O
-
 Streptococcus suis ?
-
 ?

Synonyms

Synonyms Comment Organism
SntA
-
 Streptococcus suis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.01
-
 2',3'-cGAMP pH 7.5, 37°C Streptococcus suis
0.06
-
 c-di-GMP pH 7.5, 37°C Streptococcus suis
0.08
-
 ADP-ribose pH 7.5, 37°C Streptococcus suis
0.17
-
 ADP pH 7.5, 37°C Streptococcus suis
0.28
-
 3',3'-cGAMP pH 7.5, 37°C Streptococcus suis
0.29
-
 Ap4A pH 7.5, 37°C Streptococcus suis
0.29
-
 Ap3A pH 7.5, 37°C Streptococcus suis
0.76
-
 pGpG pH 7.5, 37°C Streptococcus suis
0.85
-
 ATP pH 7.5, 37°C Streptococcus suis
1.65
-
 cyclic di-3',5'-adenylate pH 7.5, 37°C Streptococcus suis
4.98
-
 4-NPhP pH 7.5, 37°C Streptococcus suis
19.33
-
 PapA pH 7.5, 37°C Streptococcus suis
273.66
-
 bis-4NPhP pH 7.5, 37°C Streptococcus suis
290.51
-
 2',3'-cAMP pH 7.5, 37°C Streptococcus suis
318.3
-
 2',3'-cGMP pH 7.5, 37°C Streptococcus suis
323.76
-
 3'-AMP pH 7.5, 37°C Streptococcus suis
373.45
-
 2',3'-cCMP pH 7.5, 37°C Streptococcus suis
573.53
-
 3'-UMP pH 7.5, 37°C Streptococcus suis
666.55
-
 3'-GMP pH 7.5, 37°C Streptococcus suis
748.84
-
 2',3'-cUMP pH 7.5, 37°C Streptococcus suis

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.53
-
 ADP-ribose pH 7.5, 37°C Streptococcus suis
0.618
-
 2',3'-cGAMP pH 7.5, 37°C Streptococcus suis
1.57
-
 ADP pH 7.5, 37°C Streptococcus suis
1.86
-
 4-NPhP pH 7.5, 37°C Streptococcus suis
6.63
-
 Ap3A pH 7.5, 37°C Streptococcus suis
7.09
-
 Ap4A pH 7.5, 37°C Streptococcus suis
80.7
-
 c-di-GMP pH 7.5, 37°C Streptococcus suis
91.3
-
 ATP pH 7.5, 37°C Streptococcus suis
282
-
 3',3'-cGAMP pH 7.5, 37°C Streptococcus suis
383
-
 pGpG pH 7.5, 37°C Streptococcus suis
620
-
 cyclic di-3',5'-adenylate pH 7.5, 37°C Streptococcus suis
673
-
 bis-4NPhP pH 7.5, 37°C Streptococcus suis
3600
-
 2',3'-cUMP pH 7.5, 37°C Streptococcus suis
6760
-
 PapA pH 7.5, 37°C Streptococcus suis
10200
-
 2',3'-cCMP pH 7.5, 37°C Streptococcus suis
19300
-
 2',3'-cGMP pH 7.5, 37°C Streptococcus suis
28100
-
 3'-UMP pH 7.5, 37°C Streptococcus suis
73100
-
 2',3'-cAMP pH 7.5, 37°C Streptococcus suis
123000
-
 3'-AMP pH 7.5, 37°C Streptococcus suis
165000
-
 3'-GMP pH 7.5, 37°C Streptococcus suis