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Literature summary for 3.1.4.59 extracted from
- Truncation of GdpP mediates beta-lactam resistance in clinical isolates of Staphylococcus aureus (2019), J. Antimicrob. Chemother., 74, 1182-1191.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | a truncation in the cyclic diadenosine monophosphate phosphodiesterase enzyme, GdpP, is identified in 7 of the 10 Austrian isolates and 10 of the 11 UK clinical isolates of beta-lactam resistant Staphylococcus aureus. Complementation of four representative isolates with an intact copy of the GdpP gene restored susceptibility to penicillins and abolished the growth defects caused by the truncation | Staphylococcus aureus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Staphylococcus aureus | - |
- |
- |
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