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Literature summary for 3.1.4.59 extracted from

  • Ye, M.; Zhang, J.J.; Fang, X.; Lawlis, G.B.; Troxell, B.; Zhou, Y.; Gomelsky, M.; Lou, Y.; Yang, X.F.
    DhhP, a cyclic di-AMP phosphodiesterase of Borrelia burgdorferi, is essential for cell growth and virulence (2014), Infect. Immun., 82, 1840-1849 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.59

Inhibitors

Inhibitors Comment Organism Structure
Ca2+
-
 Borreliella burgdorferi
Zn2+
-
 Borreliella burgdorferi

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ may substitute for Mn2+ Borreliella burgdorferi
Mn2+ maximum activity is observed with Mn2+ as a cofactor Borreliella burgdorferi

Organism

Organism UniProt Comment Textmining
Borreliella burgdorferi O51564
-
-
Borreliella burgdorferi DSM 4680 O51564
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclic di-3',5'-adenylate + H2O
-
 Borreliella burgdorferi 5'-O-phosphonoadenylyl-(3'->5')-adenosine
-
 ?
cyclic di-3',5'-adenylate + H2O
-
 Borreliella burgdorferi DSM 4680 5'-O-phosphonoadenylyl-(3'->5')-adenosine
-
 ?

Subunits

Subunits Comment Organism
additional information PdeA is a DHH-DHHA1 domain protein Borreliella burgdorferi

Synonyms

Synonyms Comment Organism
BB0619
-
 Borreliella burgdorferi
Dhhp
-
 Borreliella burgdorferi

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
 Borreliella burgdorferi

General Information

General Information Comment Organism
physiological function DhhP is essential for Borrelia burgdorferi growth both in vitro and in the mammalian host. The conditional DhhP mutant has a dramatic increase in intracellular c-di-AMP level in comparison to the isogenic wild-type strain. Elevated cellular c-di-AMP in Borrelia burgdorferi does not result in an increased resistance to beta-lactamase antibiotics. The DhhP mutant is defective in induction of the sigmaS factor, RpoS, and the RpoS-dependent outer membrane virulence factor OspC Borreliella burgdorferi