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Literature summary for 3.1.4.59 extracted from

  • Wang, F.; He, Q.; Su, K.; Wei, T.; Xu, S.; Gu, L.
    Structural and biochemical characterization of the catalytic domains of GdpP reveals a unified hydrolysis mechanism for the DHH/DHHA1 phosphodiesterase (2018), Biochem. J., 475, 191-205.
    View publication on PubMed
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Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of the DHH/DHHA1 domain of GdpP, i.e. GdpP-C, and structures in complex with c-di-AMP, cyclic diguanosine monophosphate, and 5'-O-phosphonoadenylyl-(3'->5')-adenosine Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
5'-O-phosphonoadenylyl-(3'->5')-adenosine product inhibition, competitive Staphylococcus aureus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0997
-
 cyclic di-3',5'-adenylate pH 8.0, 37°C Staphylococcus aureus
0.145
-
 cyclic di-3',5'-adenylate pH 8.0, 37°C, presence of 0.02 mM 5'-O-phosphonoadenylyl-(3'->5')-adenosine Staphylococcus aureus

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ CdpP-C exclusively utilizes Mn2+ Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus A0A0U1MUE2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclic di-3',5'-adenylate + H2O
-
 Staphylococcus aureus 5'-O-phosphonoadenylyl-(3'->5')-adenosine
-
 ?
additional information enzyme does not hydrolyze product 5'-O-phosphonoadenylyl-(3'->5')-adenosine Staphylococcus aureus ?
-
 ?

Synonyms

Synonyms Comment Organism
CdnD
-
 Staphylococcus aureus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
 Staphylococcus aureus