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Literature summary for 3.1.4.54 extracted from

  • Tsuboi, K.; Okamoto, Y.; Ikematsu, N.; Inoue, M.; Shimizu, Y.; Uyama, T.; Wang, J.; Deutsch, D.G.; Burns, M.P.; Ulloa, N.M.; Tokumura, A.; Ueda, N.
    Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways (2011), Biochim. Biophys. Acta, 1811, 565-577.
    View publication on PubMed
Search for more literature for 3.1.4.54

Protein Variants

Protein Variants Comment Organism
additional information generation of NAPE-PLD-/- mice, phenotype, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
4-chloromercuribenzoic acid
-
 Mus musculus
Ca2+
-
 Mus musculus
DTT
-
 Mus musculus
EDTA
-
 Mus musculus
Triton X-100
-
 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates, methyl arachidonyl fluorophosphonate inhibits activation by Mg2+ slightly Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus recombinant NAPE-PLD catalyzes direct release of N-palmitoylethanolamine from N-palmitoylethanolamine plasmalogen, the reaction is also catalyzes in the brain in absence of NAPE-PLD, overview ?
-
 ?
additional information Mus musculus C57BL/6 recombinant NAPE-PLD catalyzes direct release of N-palmitoylethanolamine from N-palmitoylethanolamine plasmalogen, the reaction is also catalyzes in the brain in absence of NAPE-PLD, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57BL/6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-dioleoyl-sn-glycero-3-phospho(N-palmitoyl)ethanolamine + H2O
-
 Mus musculus 1,2-dioleoyl-sn-glycero-3-phosphate + N-palmitoyl-phosphatidylethanolamine
-
 ?
1,2-dioleoyl-sn-glycero-3-phospho(N-palmitoyl)ethanolamine + H2O
-
 Mus musculus C57BL/6 1,2-dioleoyl-sn-glycero-3-phosphate + N-palmitoyl-phosphatidylethanolamine
-
 ?
1-O-octadecenyl-2-oleoyl-sn-glycero-3-phospho(N-palmitoyl)ethanolamine + H2O
-
 Mus musculus 1-O-octadecenyl-2-oleoyl-sn-glycerol-3-phosphate + N-palmitoyl-phosphatidylethanolamine
-
 ?
additional information recombinant NAPE-PLD catalyzes direct release of N-palmitoylethanolamine from N-palmitoylethanolamine plasmalogen, the reaction is also catalyzes in the brain in absence of NAPE-PLD, overview Mus musculus ?
-
 ?
additional information substrate specificity of the brain enzyme, detailed overview Mus musculus ?
-
 ?
additional information recombinant NAPE-PLD catalyzes direct release of N-palmitoylethanolamine from N-palmitoylethanolamine plasmalogen, the reaction is also catalyzes in the brain in absence of NAPE-PLD, overview Mus musculus C57BL/6 ?
-
 ?
additional information substrate specificity of the brain enzyme, detailed overview Mus musculus C57BL/6 ?
-
 ?

Synonyms

Synonyms Comment Organism
NAPE-PLD
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

General Information

General Information Comment Organism
malfunction remarkable accumulation of 1-alkenyl-2-hydroxy-glycero-3-phospho(N-acyl)ethanolamines in the brain of NAPE-PLD-deficient mice Mus musculus
metabolism NAPE-PLD-dependent and -independent, via lysophospholipase D, N-acylphosphatidylethanolamines metabolism in the brain, overview. Brain tissue N-acylethanolamines, including anandamide, can be formed from N-acylated plasmalogen through an NAPE-PLD-independent pathway as well as by their direct release via NAPE-PLD. Mus musculus
additional information brain homogenate also form N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso pNAPEs by a Mg2+-dependent lysophospholipase D Mus musculus
physiological function NAPE-PLD is involved in formation of N-acylethanolamines, e.g. include anandamide, N-palmitoylethanolamine,, and N-oleoylethanolamine, from N-acylphosphatidylethanolamines in the brain Mus musculus