Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S42A | the mutant with 170% activity compared to the wild type enzyme is not phosphorylated at serine 42 | Homo sapiens |
S42D | the mutant with increased activity compared to the wild type enzyme is not phosphorylated at serine 42 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | Homo sapiens | - |
5'-AMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q08499 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | the enzyme is phosphorylated and activated by protein kinase A within upstream conserved region 1 and inhibited by phosphorylation at serine 42 within the N-terminal region | Homo sapiens |
Purification (Comment) | Organism |
---|---|
glutathione Sepharose column chromatography, and Superdex 200 gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3',5'-cAMP + H2O | - |
Homo sapiens | 5'-AMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cAMP-phosphodiesterase 4D7 | - |
Homo sapiens |
cyclic AMP phosphodiesterase type 4 | - |
Homo sapiens |
PDE4D7 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | isoform PDE4D7 doubles in activity after forskolin treatment | up |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform PDE4D7 is important in prostate cancer progression and ischemic stroke | Homo sapiens |