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Literature summary for 3.1.4.53 extracted from

  • Cai, Y.; Nagel, D.J.; Zhou, Q.; Cygnar, K.D.; Zhao, H.; Li, F.; Pi, X.; Knight, P.A.; Yan, C.
    Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia (2015), Circ. Res., 116, 1120-1132 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.53

Inhibitors

Inhibitors Comment Organism Structure
IC86340
-
 Homo sapiens
IC86340
-
 Mus musculus
IC86340
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3',5'-cAMP + H2O Mus musculus
-
 5'-AMP
-
 ?
3',5'-cAMP + H2O Homo sapiens
-
 5'-AMP
-
 ?
3',5'-cAMP + H2O Rattus norvegicus
-
 5'-AMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Homo sapiens
-
aorta
-
 Rattus norvegicus
-
coronary artery
-
 Homo sapiens
-
coronary artery
-
 Rattus norvegicus
-
saphenous vein
-
 Homo sapiens
-
saphenous vein
-
 Rattus norvegicus
-
smooth muscle cell
-
 Mus musculus
-
smooth muscle cell
-
 Homo sapiens
-
smooth muscle cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
 Mus musculus 5'-AMP
-
 ?
3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?
3',5'-cAMP + H2O
-
 Rattus norvegicus 5'-AMP
-
 ?

Synonyms

Synonyms Comment Organism
cAMP-phosphodiesterase 1C
-
 Mus musculus
cAMP-phosphodiesterase 1C
-
 Homo sapiens
cAMP-phosphodiesterase 1C
-
 Rattus norvegicus
PDE1C
-
 Mus musculus
PDE1C
-
 Homo sapiens
PDE1C
-
 Rattus norvegicus

Expression

Organism Comment Expression
Homo sapiens isoform PDE1C expression is highly induced in neointimal smooth muscle cells of human coronary arteries up
Mus musculus isoform PDE1C expression is low in contractile smooth muscle cells but drastically elevated in synthetic smooth muscle cells in vitro and in various mouse vascular injury models in vivo up

General Information

General Information Comment Organism
malfunction in cultured smooth muscle cells, isoform PDE1C deficiency or PDE1 inhibition attenuates smooth muscle cell proliferation and migration Mus musculus
malfunction in cultured smooth muscle cells, isoform PDE1C deficiency or PDE1 inhibition attenuates smooth muscle cell proliferation and migration Homo sapiens
malfunction in cultured smooth muscle cells, isoform PDE1C deficiency or PDE1 inhibition attenuates smooth muscle cell proliferation and migration Rattus norvegicus
metabolism a transmembrane-adenylyl-cyclase-cAMP-protein kinase A cascade modulated by isoform PDE1C is critical in regulating platelet-derived growth factor -receptor-beta degradation Mus musculus
metabolism a transmembrane-adenylyl-cyclase-cAMP-protein kinase A cascade modulated by isoform PDE1C is critical in regulating platelet-derived growth factor -receptor-beta degradation Homo sapiens
metabolism a transmembrane-adenylyl-cyclase-cAMP-protein kinase A cascade modulated by isoform PDE1C is critical in regulating platelet-derived growth factor -receptor-beta degradation Rattus norvegicus
physiological function cAMP-phosphodiesterase 1C plays a role in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia Mus musculus
physiological function cAMP-phosphodiesterase 1C plays a role in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia Homo sapiens
physiological function cAMP-phosphodiesterase 1C plays a role in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia Rattus norvegicus