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Literature summary for 3.1.4.53 extracted from

  • Wahlang, B.; McClain, C.; Barve, S.; Gobejishvili, L.
    Role of cAMP and phosphodiesterase signaling in liver health and disease (2018), Cell. Signal., 49, 105-115 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.53

Inhibitors

Inhibitors Comment Organism Structure
ASP9831
-
 Homo sapiens
Caffeine
-
 Homo sapiens
pentoxifylline
-
 Homo sapiens
resveratrol
-
 Homo sapiens
roflumilast
-
 Homo sapiens
theophylline
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3',5'-cAMP + H2O Homo sapiens
-
 5'-AMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
hepatocyte
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?

Synonyms

Synonyms Comment Organism
cAMPspecific PDE
-
 Homo sapiens
PDE4 isoform Homo sapiens

General Information

General Information Comment Organism
physiological function hepatic isoforms PDE4A, B and D play a causal role in the development of liver injury and fibrosis Homo sapiens