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Literature summary for 3.1.4.53 extracted from

  • Bergeron, A.; Aragon, J.P.; Guillemette, C.; Hebert, A.; Sullivan, R.; Blondin, P.; Richard, F.J.
    Characterization of cAMP-phosphodiesterase activity in bovine seminal plasma (2016), Andrology, 4, 1123-1130 .
    View publication on PubMed
Search for more literature for 3.1.4.53

Inhibitors

Inhibitors Comment Organism Structure
3-isobutyl-methylxanthine inhibitor of all PDE isoforms except PDE8 Bos taurus
Cilostamide inhibitor of isoform PDE3 Bos taurus
additional information the major enzyme activity (isoform PDE8) is insensitive towards 3-isobutyl-methylxanthine Bos taurus
papaverine inhibitor of isoform PDE10 Bos taurus
rolipram inhibitor of isoform PDE4 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3',5'-cAMP + H2O Bos taurus
-
 5'-AMP
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
HiTrap-Q Sepharose column chromatography Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
epididymal fluid
-
 Bos taurus
-
epididymis
-
 Bos taurus
-
seminal plasma
-
 Bos taurus
-
seminal vesicle
-
 Bos taurus
-
spermatozoon
-
 Bos taurus
-
testis
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
 Bos taurus 5'-AMP
-
 ?

Subunits

Subunits Comment Organism
? x * 60000, isoform PDE10 appears on SDS-PAGE as bands of 75000 and 60000 Da in size Bos taurus
? x * 75000, isoform PDE10 appears on SDS-PAGE as bands of 75000 and 60000 Da in size Bos taurus

Synonyms

Synonyms Comment Organism
cAMP-PDE
-
 Bos taurus
cAMP-phosphodiesterase
-
 Bos taurus
PDE10A isoform Bos taurus
PDE3 isoform Bos taurus
PDE4 isoform Bos taurus
PDE8 isoform Bos taurus