Literature summary for 3.1.4.53 extracted from

Schwebs, D.J.; Nguyen, H.N.; Miller, J.A.; Hadwiger, J.A.
Loss of cAMP-specific phosphodiesterase rescues spore development in G protein mutant in Dictyostelium (2014), Cell. Signal., 26, 409-418.

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Organism

Organism	UniProt	Comment	Textmining
Dictyostelium discoideum	Q23917	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
RegA	-	Dictyostelium discoideum

General Information

General Information	Comment	Organism
physiological function	mutation in cAMP-specific phosphodiesterase RegA in cells lacking either G protein Galpha2 or Galpha4 subunits has no major effects on developmental morphology but enriches the distribution of the Galpha mutant cells to the prespore/prestalk border in chimeric aggregates. The loss of RegA function has no effect on Galpha4-mediated folate chemotaxis. The RegA gene disruption in cells lacking Galpha4 results in a substantial rescue and acceleration of spore production. This rescue in sporulation requires cell autonomous signaling. Intercellular signals from strains lacking RegA increase the expression of the prestalk gene ecmB and accelerate the vacuolization of stalk cells. Intercellular signaling from the strain lacking both Galpha4 and RegA do not induce ecmA gene expression indicating cell-type specificity in the promotion of prestalk cell development. RegA gene disruption in a Galpha4 overexpression strain does not result in precocious sporulation or stalk cell development	Dictyostelium discoideum

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Release 2023.1 (January 2023)