Literature summary for 3.1.4.53 extracted from

Maschi, O.; Cero, E.D.; Galli, G.V.; Caruso, D.; Bosisio, E.; DellAgli, M.
Inhibition of human cAMP-phosphodiesterase as a mechanism of the spasmolytic effect of Matricaria recutita L (2008), J. Agric. Food Chem., 56, 5015-5020.

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Inhibitors

Inhibitors	Comment	Organism	Structure
apigenin	-	Homo sapiens
apigenin-7-O-glucoside	-	Homo sapiens
chamomile	inhibits cAMP-PDE activity	Homo sapiens
hyperoside	-	Homo sapiens
luteolin	-	Homo sapiens
luteolin-7-O-glucoside	-	Homo sapiens
additional information	not inhibited by alpha-bisabolol, caffeic acid, ferulic acid, quinic acid, rutin, chlorogenic acid, herniarin, and umbelliferone	Homo sapiens
patuletin-7-O-glucoside	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood platelet	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3',5'-cAMP + H2O	-	Homo sapiens	5'-AMP	-	?

Synonyms

Synonyms	Comment	Organism
cAMP-PDE	-	Homo sapiens
cAMP-phosphodiesterase	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0013	-	-	Homo sapiens	luteolin
0.0041	-	-	Homo sapiens	apigenin
0.0102	-	-	Homo sapiens	apigenin-7-O-glucoside
0.0118	-	-	Homo sapiens	hyperoside
0.0149	-	-	Homo sapiens	luteolin-7-O-glucoside
0.0149	-	-	Homo sapiens	patuletin-7-O-glucoside

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Release 2023.1 (January 2023)