Literature summary for 3.1.4.53 extracted from

Chan, A.L.; Huang, H.L.; Chien, H.C.; Chen, C.M.; Lin, C.N.; Ko, W.C.
Inhibitory effects of quercetin derivatives on phosphodiesterase isozymes and high-affinity [3H]-rolipram binding in guinea pig tissues (2008), Invest. New Drugs, 26, 417-424.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone	Ro20-1724	Cavia porcellus
additional information	not inhibited by quercetin-3,7,3',4'-O-tetramethylether	Cavia porcellus
quercetin	-	Cavia porcellus
quercetin-3,5,7,3',4'-O-pentaacetate	-	Cavia porcellus
quercetin-3,5,7,3',4'-O-pentamethylether	-	Cavia porcellus
quercetin-3,7,4'-O-trimethylether	ayanin	Cavia porcellus
quercetin-3-O-methyl-5,7,3',4'-O-tetraacetate	-	Cavia porcellus
quercetin-3-O-methylether	-	Cavia porcellus
rolipram	-	Cavia porcellus

Organism

Organism	UniProt	Comment	Textmining
Cavia porcellus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
partially purified by Q-Sepharose column chromatography	Cavia porcellus

Source Tissue

Source Tissue	Comment	Organism	Textmining
lung	-	Cavia porcellus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3',5'-cAMP + H2O	-	Cavia porcellus	5'-AMP	-	?

Synonyms

Synonyms	Comment	Organism
PDE4	cAMP-specific enzyme	Cavia porcellus
phosphodiesterase-4	-	Cavia porcellus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0023	-	PDE4	Cavia porcellus	rolipram
0.0039	-	PDE4	Cavia porcellus	quercetin-3-O-methyl-5,7,3',4'-O-tetraacetate
0.0051	-	PDE4	Cavia porcellus	quercetin-3,5,7,3',4'-O-pentamethylether
0.0087	-	PDE4	Cavia porcellus	4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
0.0099	-	PDE4	Cavia porcellus	quercetin
0.0158	-	PDE4	Cavia porcellus	quercetin-3,7,4'-O-trimethylether
0.0185	-	PDE4	Cavia porcellus	quercetin-3,5,7,3',4'-O-pentaacetate
0.0285	-	PDE4	Cavia porcellus	quercetin-3-O-methylether

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Release 2023.1 (January 2023)