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Literature summary for 3.1.4.53 extracted from

  • Goldhoff, P.; Warrington, N.M.; Limbrick, D.D.; Hope, A.; Woerner, B.M.; Jackson, E.; Perry, A.; Piwnica-Worms, D.; Rubin, J.B.
    Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression (2008), Clin. Cancer Res., 14, 7717-7725.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.53

Inhibitors

Inhibitors Comment Organism Structure
rolipram PDE4 inhibition by rolipram can promote regression of malignant brain tumors when administered as an adjunct to established therapies Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
DAOY cell
-
 Homo sapiens
-
ependymoma cell
-
 Homo sapiens
-
meningioma cell
-
 Homo sapiens
-
oligodendroglioma cell
-
 Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
 Homo sapiens 5'-AMP
-
 ?

Synonyms

Synonyms Comment Organism
cAMP phosphodiesterase-4
-
 Homo sapiens
cyclic AMP phosphodiesterase-4
-
 Homo sapiens
PDE4
-
 Homo sapiens
PDE4A subfamily of PDE4 Homo sapiens