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Literature summary for 3.1.4.53 extracted from

  • Rascon, A.; Soderling, S.H.; Schaefer, J.B.; Beavo, J.A.
    Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei (2002), Proc. Natl. Acad. Sci. USA, 99, 4714-4719.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.53

Cloned(Commentary)

Cloned (Comment) Organism
-
 Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
3-isobutyl-1-methylxanthine
-
 Trypanosoma brucei
dipyridamole
-
 Trypanosoma brucei
etazolate
-
 Trypanosoma brucei
papaverine
-
 Trypanosoma brucei

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0024
-
 adenosine 3',5'-cyclic phosphate
-
 Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei Q9GQU6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine 3',5'-cyclic phosphate + H2O
-
 Trypanosoma brucei adenosine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
TbPDE2B
-
 Trypanosoma brucei

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.027
-
-
 Trypanosoma brucei dipyridamole
0.127
-
-
 Trypanosoma brucei papaverine
0.127
-
-
 Trypanosoma brucei etazolate
0.304
-
-
 Trypanosoma brucei 3-isobutyl-1-methylxanthine