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Literature summary for 3.1.4.53 extracted from

  • Rena, G.; Begg, F.; Ross, A.; Mackenzie, C.; McPhee, I.; Campbell, L.; Huston, E.; Sullivan, M.; Houslay, M.D.
    Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic AMP-specific phosphodiesterase PDE4A10 (2001), Mol. Pharmacol., 59, 996-1011.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of the engineered human PDE4A10 open reading frame in COS7 cells allows detection of a 121000 Da protein in both soluble and particulate fractions. PDE4A10 is localized primarily to the perinuclear region of COS7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
rolipram
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine 3',5'-cyclic phosphate + H2O
-
Homo sapiens adenosine 5'-phosphate
-
?

Synonyms

Synonyms Comment Organism
cyclic AMP-specific phosphodiesterase
-
Homo sapiens
PDE4A10
-
Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
55
-
soluble HSPDE4A10 is more thermostable (T0.5: 11 min) than the particulate enzyme (T0.5: 5 min) Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00005
-
-
Homo sapiens rolipram