Literature summary for 3.1.4.53 extracted from

Bolger, G.B.; Peden, A.H.; Steele, M.R.; MacKenzie, C.; McEwan, D.G.; Wallace, D.A.; Huston, E.; Baillie, G.S.; Houslay, M.D.
Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2 (2003), J. Biol. Chem., 278, 33351-33363.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in COS7 cells	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
rolipram	-	Rattus norvegicus
XAP2	noncompetitive inhibition, aryl-hydrocarbon receptor-interacting protein XAP2 inhibits PDE4A5 activity by XAP2 does not require any intermediate proteins. XAP2 inhibits PDE4A5 and not other PDE4 isoforms	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	aryl-hydrocarbon receptor-interacting protein XAP2 attenuates the ability of cAMP-dependent protein kinase to phosphorylate PDE4A5	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
adenosine 3',5'-cyclic phosphate + H2O	attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2	Rattus norvegicus	adenosine 5'-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
PDE4A5	-	Rattus norvegicus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000099	-	XAP2	-	Rattus norvegicus
0.074	-	rolipram	-	Rattus norvegicus

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Release 2023.1 (January 2023)