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Literature summary for 3.1.4.53 extracted from

  • McLaughlin, M.M.; Cieslinski, L.B.; Burman, M.; Torphy, T.J.; Livi, G.P.
    A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA (1993), J. Biol. Chem., 268, 6470-6476.
    View publication on PubMed
Search for more literature for 3.1.4.53

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(R)-rolipram
-
 Homo sapiens
denbufylline
-
 Homo sapiens
additional information no inhibition by siguazodan or zaprinast Homo sapiens
Ro20-1724
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0043
-
 adenosine 3',5'-cyclic phosphate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q07343
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
frontal lobe
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
additional information PDE IVB is not detected in Placenta, liver, kidney, or pancreas Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine 3',5'-cyclic phosphate + H2O
-
 Homo sapiens adenosine 5'-phosphate
-
 ?
additional information no hydrolysis of cGMP Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cAMP-specific phosphodiesterase
-
 Homo sapiens
PDE IVB
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000085
-
 (R)-rolipram
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0005
-
-
 Homo sapiens denbufylline
0.0022
-
-
 Homo sapiens Ro20-1724