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Literature summary for 3.1.4.53 extracted from
- Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase (2000), Biochem. Biophys. Res. Commun., 272, 186-192.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Sf9 insect cells | Mus musculus |
| expression in Sf9 insect cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-isobutyl-1-methyl-xanthine | - |
Mus musculus |  |
| 3-isobutyl-1-methylxanthine | - |
Homo sapiens | |
| dipyridamole | - |
Homo sapiens | |
| dipyridamole | - |
Mus musculus | |
| additional information | zaprinast, rolipram, and milrinone do not significantly inhibit PDE7B | Homo sapiens | |
| additional information | zaprinast, rolipram, and milrinone do not significantly inhibit PDE7B | Mus musculus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0001 | - |
adenosine 3',5'-cyclic phosphate | - |
Mus musculus | |
| 0.0002 | - |
adenosine 3',5'-cyclic phosphate | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9NP56 | - |
- |
| Mus musculus | Q9QXQ1 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| adenosine 3',5'-cyclic phosphate + H2O | - |
Mus musculus | adenosine 5'-phosphate | - |
? | |
| adenosine 3',5'-cyclic phosphate + H2O | - |
Homo sapiens | adenosine 5'-phosphate | - |
? | |
| additional information | PDE7B does not hydrolyse cGMP | Mus musculus | ? | - |
? | |
| additional information | PDE7B does not hydrolyse cGMP | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDE7B | - |
Mus musculus |
| PDE7B | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00051 | - |
pH 7.4, 30°C | Mus musculus | dipyridamole | |
| 0.00194 | - |
pH 7.4, 30°C | Homo sapiens | dipyridamole | |
| 0.00381 | - |
pH 7.4, 30°C | Mus musculus | 3-isobutyl-1-methyl-xanthine | |
| 0.00737 | - |
pH 7.4, 30°C | Homo sapiens | 3-isobutyl-1-methylxanthine | |
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