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Literature summary for 3.1.4.53 extracted from

  • Sasaki, T.; Kotera, J.; Yuasa, K.; Omori, K.
    Identification of human PDE7B, a cAMP-specific phosphodiesterase (2000), Biochem. Biophys. Res. Commun., 271, 575-583.
    View publication on PubMed
Search for more literature for 3.1.4.53

Cloned(Commentary)

Cloned (Comment) Organism
recombinant PDE7B expressed in transfected COS-7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-isobutyl-1-methylxanthine
-
 Homo sapiens
dipyridamole
-
 Homo sapiens
E4021
-
 Homo sapiens
additional information EHNA, milrinone, rolipram, and zaprinast, which are PDE2, PDE3, and PDE4 inhibitors, respectively, do not inhibit the PDE7B activity up to concentrations of 0.100 mM Homo sapiens
SCH51866
-
 Homo sapiens
vinpocetine
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00013
-
 adenosine 3',5'-cyclic phosphate PDE7B expressed in transfected COS-7 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
caudate nucleus
-
 Homo sapiens
-
caudate putamen
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
occipital pole
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine 3',5'-cyclic phosphate + H2O
-
 Homo sapiens adenosine 5'-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PDE7B
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0011
-
-
 Homo sapiens dipyridamole
0.0015
-
 PDE7B expressed in transfected COS-7 cells Homo sapiens SCH51866
0.0099
-
-
 Homo sapiens 3-isobutyl-1-methylxanthine
0.015
-
-
 Homo sapiens E4021
0.059
-
-
 Homo sapiens vinpocetine