Application | Comment | Organism |
---|---|---|
medicine | enzyme variants PDE4B and/or PDE4D regulate cell growth through cAMP targets in the HMG malignant melanoma cell | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ro-20-1724 | inhibition of PDE4, resulting in increased intacelular cAMP | Homo sapiens | |
rolipram | inhibition of PDE4, resulting in increased intacelular cAMP | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | enzyme variants PDE4B and/or PDE4D regulate cell growth through cAMP targets in the HMG malignant melanoma cell | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform PDE4 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
melanoma cell line | gingiva-derived malignant melanoma cell, expression of variants PDE4B and PDE4D | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | enzyme variants PDE4B and/or PDE4D regulate cell growth through cAMP targets in the HMG malignant melanoma cell | Homo sapiens | ? | - |
? |