Literature summary for 3.1.4.53 extracted from

Xiong, Y.; Lu, H.T.; Li, Y.; Yang, G.F.; Zhan, C.G.
Characterization of a catalytic ligand bridging metal ions in phosphodiesterases 4 and 5 by molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations (2006), Biophys. J., 91, 1858-1867.

Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular dynamics simulations. The second bridging ligand in the active site is HO- rather than H2O, serving as a nucleophile to initialize the catalytic hydrolysis of cAMP	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform PDE4	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)